New skin model

It is well known that lipids (fatty substances) can have a positive effect on skin. A new project at the FRAME laboratory will enable close investigation of how lipids are absorbed to create those effects. The project will involve building three-dimensional models from keratinocytes, fibroblasts, melanocytes and immune cells. They will be isolated directly from […]

February 27th, 2015|Research|Comments Off

1977 – First alternatives developed for skin irritants

Prior to 1977, tests for epidermal responses to substances were carried out primarily on animals, which generally produced misleading results. In order to effectively, and safely, investigate reactions in human subjects Griffith and Buehler developed the ‘repeated-insult patch test’. By concentrating and localising samples of the substance to a small, confined grid of 12mm, researchers […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

Current laboratory cell models

Using donated human cells to investigate human reactions.  The FRAME Alternatives Laboratory uses cells derived from human tissues to produce biologically relevant in vitro models of human organs, which behave and respond in the way they would in the body. Rather than growing cells as a single layer on plastic surfaces, it uses three dimensional scaffolds, […]

June 26th, 2014|Research|Comments Off