replacement

Students drink coffee to replace animal tests

A university in the United Arab Emirates has introduced a human-based experiment as a way of replacing animal models of the effects of drugs on body organs. Medical students now dose themselves with coffee to observe how the stimulant properties of caffeine affect them.

The new scheme is described in the latest edition of PiLAS (Perspectives […]

June 8th, 2015|News, Press|Comments Off

First FRAME debate is a huge success

The first FRAME debate was a huge success. It brought together experts from across the fields of industry,  academia, politics, animal welfare and science promotion to discuss the proposition: Total animal replacement in human medicine is a realistic goal.

The speakers were: Dr Brian Burlinson, VP Safety Assessment and Principal Scientist at Huntingdon Life Sciences;  Dr […]

April 24th, 2015|Press|Comments Off

What will drive the end of animal testing?

In spite of campaigns by many bodies and individuals for an end to animal experimentation the numbers used in procedures in UK laboratories continue to rise. If a change is to happen there must be a driver behind it. Here we discuss some of the forces involved in the question of implementing Replacement.

We would welcome […]

April 1st, 2015|News|Comments Off

Home Office Three Rs progress report

The Home Office has issued a progress report on what it is doing to reduce the use of animals in scientific research. The department set out plans in a document last February, which included three strategic priorities.

They were:

advance the use of the ThreeRs within the UK;
use international leadership to influence the uptake and adoption of […]

March 26th, 2015|Press, Rightbox|Comments Off

2010 – Organ-on-a-chip technology introduced

One of the most substantial modern breakthroughs in alternatives research came from the Wyss Institute for Biologically Inspired Engineering at Harvard University in the form of the ‘organ-on-a-chip’ model in 2010. Scientists at the Institute have successfully produced a small silicon chip, no more than a few square inches, containing isolated living cells and tissues […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

2000- 3T3 Neutral Red Uptake (NRU) Phototoxicity Assay

In vitro phototoxicity tests measure skin irritation responses to agents without the need for an immune response.  This is accomplished by comparing the capacity for cell cultures to display a dye that is visible under UVA light in the presence or absence of the cytotoxic compound in question.  Such tests replace the need to test substances […]

June 26th, 2014|Timeline, TL_Alternatives|Comments Off

1996 – First successful mammal cloning – Dolly the Sheep

In July 1996, the Roslin Institute of the University of Edinburgh accomplished one of the greatest and most controversial feats in modern science with the successful cloning of a mammalian adult cell. Dolly the sheep would be the first mammal born via the process of somatic cell transfer and would provide insight into the possibilities […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

1980s – Development of various computer models

The 1980s saw a huge drive towards the use of computer simulation and modelling software to reduce or replace the need for live animals in testing. The capacity for computers to help in diagnosing, imagery, recording, statistical analysis, and simulation provides researchers with a tool to greatly improve the efficiency, speed, and use of animals […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

1978 – Synthetic production of human insulin

Prior to 1978, insulin for human use was purified from animal sources, commonly pigs or dogs. It was the work conducted by researchers at Genentech and City of Hope Medical Research Centre that would provide the progression away from the necessity for animals to produce insulin by successfully synthesising ‘human-insulin’. By editing the DNA of […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

1978 – First human stem cells discovered

Stem cell research shifted to humans in 1978 when Dr Gregor Pindull published findings of haematopoietic stem cells (HSCs) in human cord blood. Previous work had been able to identify similar cells in other mammalian species. This was the first observation of human stem cells that would give rise to similar cells and signalled an […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off