Cell based models to help identify potential new analgesics. Research focussing on elucidating the key molecular mechanisms by which fatty acid metabolites or lipids signal to ion channel proteins involved in pain detection in sensory neurons, that is, the chemical pathways by which the body feels pain. The overall aim of the project is to [...]
Medical imaging took a noteworthy step forward with the introduction of the capacity for 3-dimensional imagery during the early 2000’s. Enhanced computer software and imaging devices, such as the CT, PET, and MRI scans have provided researchers the ability to view target areas with exceptional levels of detail further reducing the necessity for vivisection. 3D [...]
Major advancements in medical imagery took place in the 1980s with the advent of Computer Radiology, Medical Resonance Imaging, and Colour Doppler ultrasound. Each technology varies in its conception and applications, yet all would prove pivotal in the movement towards non-invasive techniques for diagnosis, surgery, and drug testing.
Prior to 1978, insulin for human use was purified from animal sources, commonly pigs or dogs. It was the work conducted by researchers at Genentech and City of Hope Medical Research Centre that would provide the progression away from the necessity for animals to produce insulin by successfully synthesising ‘human-insulin’. By editing the DNA of [...]
Prior to 1977, tests for epidermal responses to substances were carried out primarily on animals, which generally produced misleading results. In order to effectively, and safely, investigate reactions in human subjects Griffith and Buehler developed the ‘repeated-insult patch test’. By concentrating and localising samples of the substance to a small, confined grid of 12mm, researchers [...]
German physicist Wilhelm Rontgen is recognised as the first individual to study the properties of X-rays in 1895. Roughly a decade later, X-rays would be adopted as a medical tool to non-invasively observe patients. The ability to study a subject without the need for vivisection provided an important new alternate methodology to many animal studies. [...]