drug testing

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FRAME response to French drug trial incident

Statement from the FRAME Trustees: The catastrophic adverse effects reported last week in a clinical trial undertaken in France were unexpected and extremely surprising. One of six people treated with repeated doses of a new investigational drug in a Phase I clinical trial was initially left brain dead and then died, four others had severe [...]

January 19th, 2016|News|Comments Off on FRAME response to French drug trial incident

Why FRAME is right to be concerned about dog use in biomedical research

Recently FRAME and the Kennel Club co-authored an open letter to The Rt Hon Greg Clark, MP, Secretary of State for Communities and Local Government, in which we expressed our disappointment at the decision to grant planning permission for establishment of a dog breeding centre in East Yorkshire. We asked “why is breeding of dogs [...]

September 24th, 2015|News, Press|Comments Off on Why FRAME is right to be concerned about dog use in biomedical research

Students drink coffee to replace animal tests

A university in the United Arab Emirates has introduced a human-based experiment as a way of replacing animal models of the effects of drugs on body organs. Medical students now dose themselves with coffee to observe how the stimulant properties of caffeine affect them. The new scheme is described in the latest edition of PiLAS [...]

June 8th, 2015|News, Press|Comments Off on Students drink coffee to replace animal tests

Cynomolgus monkeys and paracetamol: background paper

Cynomolgus monkeys are resistant to drug induced liver injury caused by paracetamol by Dr Gerry Kenna Prior to their registration for use in humans, all new drugs are subjected to a large battery of safety studies. These include an extensive series of investigations in experimental animals, which are undertaken in compliance with well-established regulatory guidelines, [...]

October 30th, 2014|Background, Press, Rightbox|Comments Off on Cynomolgus monkeys and paracetamol: background paper

New research casts doubt on monkeys as drug testing model

FRAME is calling for increased investment in cell-based and computer methods of drug testing following new research that demonstrates serious flaws in an animal model. Cynomolgus monkeys are considered a valuable species for drug testing because of their size and their relatively close genetic parallels with humans. Now new experiments to investigate how the liver [...]

October 30th, 2014|Press, Rightbox|Comments Off on New research casts doubt on monkeys as drug testing model