alternatives

Home Office Three Rs progress report

The Home Office has issued a progress report on what it is doing to reduce the use of animals in scientific research. The department set out plans in a document last February, which included three strategic priorities.

They were:

advance the use of the ThreeRs within the UK;
use international leadership to influence the uptake and adoption of […]

March 26th, 2015|Press, Rightbox|Comments Off

Animal-free challenge for young researchers

Young scientists who wish to go into a career without ever being expected to use animals need to be determined, resourceful and tenacious. That is the conclusion of new research published in FRAME’s  online discussion board PiLAS. It is based on a survey into attitudes faced by young scientists, carried out as part of the […]

March 24th, 2015|News|Comments Off

2010 – Organ-on-a-chip technology introduced

One of the most substantial modern breakthroughs in alternatives research came from the Wyss Institute for Biologically Inspired Engineering at Harvard University in the form of the ‘organ-on-a-chip’ model in 2010. Scientists at the Institute have successfully produced a small silicon chip, no more than a few square inches, containing isolated living cells and tissues […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

2007- REACH guidelines introduced

In 2007 the European Union consolidated numerous regulations and doctrine from its member states regarding the use of chemicals into one directive.  The REACH (Registration, Evaluation, Authorisation, and restriction of Chemicals) guidelines’ objective is to protect both human and environmental health while promoting proper trade within the EU as well as alternative methodology.  As a […]

January 26th, 2015|Timeline, TL_legislation|Comments Off

2000s – Significant advancements in real-time 3D imaging

Medical imaging took a noteworthy step forward with the introduction of the capacity for 3-dimensional imagery during the early 2000’s. Enhanced computer software and imaging devices, such as the CT, PET, and MRI scans have provided researchers the ability to view target areas with exceptional levels of detail further reducing the necessity for vivisection. 3D […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

2000s – Human Genome Project successfully maps human DNA

In June 2006 it was announced that the first working draft of the full human DNA sequence had been released by the Human Genome Project. In the years following researchers all over the world have used this resource to gain insight into a number of fields while reducing the need for animal testing. By studying […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

1996 – First successful mammal cloning – Dolly the Sheep

In July 1996, the Roslin Institute of the University of Edinburgh accomplished one of the greatest and most controversial feats in modern science with the successful cloning of a mammalian adult cell. Dolly the sheep would be the first mammal born via the process of somatic cell transfer and would provide insight into the possibilities […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

Early 1990s: First reconstituted human epidermis (RHE) skin model

Commercially available artificial human skin models developed in the early 1990s provided an extremely useful alternative for researchers studying in vitro skin corrosion and irritation, as well as topical responses and phototoxicity.  Prior to the development of models such as EpiSkin, EpiDerm, EST1000, and Living Skin Equivalent (LHE), in vivo tests on either human or animals subjects were […]

July 14th, 2014|Timeline, TL_Alternatives|Comments Off

1989 – replacement for the Draize eye irritation test

Devised in 1944 by FDA toxicologist John Draize, the Draize eye irritation test was developed as an acute toxicology test for cosmetic compounds. An extremely invasive procedure, it involves the application of 0.5ml or 0.5g of a test substance to the eye of a conscious, restrained animal – commonly albino rabbits.  Before 1989, no alternative to […]

March 13th, 2015|Timeline, TL_Alternatives|Comments Off

1983 – Polymerase Chain Reaction developed

Since its original development by American biochemist Kary Mullis in 1983, the Polymerase Chain Reaction (PCR) has become one of the most widely used and important technologies in molecular biology.  The ability for researchers to target a specific section of DNA and recreate multiple copies of identical sequences provides an invaluable tool for a variety […]

July 25th, 2014|Timeline, TL_Alternatives|Comments Off