1991 – LD50 test banned

The highly controversial Median Lethal Dose Test, or LD50, was developed by J. W. Trevan in 1927 as a means to determine characteristics in acute toxicity. However, due to the necessity to terminate large numbers of test subjects as a requisite of the test it received heavy criticism. In 1991 the UK Government decided upon […]

May 27th, 2014|Timeline, TL_legislation|Comments Off

1991 – FRAME Alternatives Laboratory founded

The FRAME Alternatives Laboratory (FAL) was opened in 1991 as part of the University of Nottingham’s medical school housed in the Queen’s Medical Centre.  Under the direction of Dr Richard Clothier, the FAL established itself as a leading laboratory for alternatives research.  This tradition has continued under Dr Andrew Bennett who replaced Dr Clothier in […]

January 29th, 2015|Timeline, TL_Alternatives|Comments Off

1991 – Formation of ECVAM

In 1991 the European Union conceptualised the European Centre for the Validation of Alternative Methods (ECVAM) and, under the stewardship of Michael Balls, became an operational research unit in 1992. Based in Ispra, Italy ECVAM’s ‘main goal is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences […]

May 27th, 2014|Timeline, TL_Social|Comments Off