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The Journal


Alternatives to Laboratory Animals - ATLA

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Papers List

List of papers, year 2007

Balls, M.   Alternatives to animal experiments: Time to focus on Replacement    AATEX, 12, 145-154   [Abstract]   Contact publisher

Sun, Y., Alexander, S.P.H., Garle, M.J., Gibson, .L., Hewitt, K., Murphy, S.P., Kendall, D.A. and Bennett, A.J.   Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism    British Journal of Pharmacology, 152, 734-743 (2007)   [Abstract]   [Purchase from publisher]

Scrivens, M. Bhogal, N.   The use of human cell line reporter gene-based assays in chemical toxicity testing    Toxicology in Vitro, 21, 1233-1240 (2007)   [Abstract]   [Purchase from publisher]

Ruben, L., Clothier, R.H. and Balls, M.   Cancer Resistance in Amphibians    ATLA, 35, 463-470m (2007)   [Abstract]    [PDF]

Reid, L., Khammo, N. and Clothier, R.H.   An Evaluation of the Effects of Photoactivation of Bithionol, Amiodarone and Chlorpromazine on Human Keratinocytes In Vitro    ATLA, 35, 471-485 (2007)   [Abstract]    [PDF]

Kinsner-Ovaskainen, A., Clemedson , C., Cole, T., Clothier, R., Coecke, S., O'Connor, J-E., Blaauboer, B., Gómez-Lechón, M-J., Vericat, J-A., Forsby,A., Ryan, M.P., Castell, J., Risteli, L. and Wendel, A.    Optimisation and pre-validation of an in vitro test strategy for predicting human acute toxicity: Progress of the “A-Cute-Tox” projec    Toxicology Letters, 172, S82-S83 (2007)   [Abstract]   [Purchase from publisher]

Khammo, N., Ogilvie, J. and Clothier, R.H.   Development of an Innervated Model of Human Skin    ATLA, 35, 487-491 (2007)   [Abstract]    [PDF]

Hurst,H.S., Clothier, R.H. and Pratten, M.   An evaluation of a novel chick cardiomyocyte micromass culture assay with two teratogens/embyrotoxins associated with heart defects    ATLA, 35, 505-514 (2007)   [Abstract]    [PDF]

Hudon, M.   Why do numbers of laboratory animal procedures conducted continue to rise? An analysis of the Home Office Statistics of Scientific Procedures on Living Animals: Great Britain 2005    ATLA, 35, 177-187m (2007)   [Abstract]    [PDF]

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. and Garrod, J.F.   An integrated decision-tree testing strategy for skin sensitisation with respect fo the requirements of the EU REACH legislation    ATLA, 35, 683-697 (2007)   [Abstract]    [PDF]

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. and Garrod, J.F.   Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation    ATLA, 35, 673-682 (2007)   [Abstract]    [PDF]

Grindon, C.   The new EU REACH regulation has finally been adopted: is this the end of the campaign trail ... or just the begining    ATLA, 35, 239-242 (2007)   [Abstract]    [PDF]

Gray, A.C., McLeod, J.D. and Clothier, R.H.   A review of in vitro modelling approaches to the identification and modulation of aquamous metaplasia in the human tracheobronchial epithelium    ATLA 35, 493-504 (2007)   [Abstract]    [PDF]

Gray, A.C., Clothier, R.H. and McLeod, J.D.   Identification and manipulation of transglutaminase isoforms and activity for the detection of squamous metaplasia in tracheobronchial cells in vitro    Toxicology, 231, 118-119 (2007)   [Abstract]   [Purchase from publisher]

Erhuma, A., Salter, A.M., Scully, D.V., Langley-Evans, S.C . and Bennett, A.J.   Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat.    American Journal of Physiology - Endocrinology and Metabolism, 292, E1702-E1714 (2007)   [Abstract]   [Purchase from publisher]

Erhuma, A., Bellinger, L., Langley-Evans, S.C. and Bennett, A.J.   Prenatal exposure to undernutrition and programming of responses to high-fat feeding the rat    British Journal of Nutrition, 98, 517-524 (2007)   [Abstract]   [Purchase from publisher]

Constantin, D., Constantin-Teodosiu, D., Layfield, R., Tsintzas, K., Bennett, A.J. and Greenhaff, P.L.   PPAR delta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle.    Journal of Physiology, 583, 381-390 (2007)   [Abstract]   [Purchase from publisher]

Combes, R.D.   Alternatives to animal testing.    In: Comprehensive Medicinal Chemistry II Volume I, pp 463-487 (2007)   [Abstract]   [Purchase from publisher]

Combes, R.D.   The FRAME Research Programme under the direction of Dr Richard Clothier    ATLA, 35, 525-530 (2007)   [Abstract]    [PDF]

Combes, R.   Developing, validating and using test batteries and tired (hierarchical) testing schemes    ATLA, 35, 375-378 (2007)   [Abstract]    [PDF]

Combes, R., Grindon, C., Cronin, M.T.D., Roberts, D.W. and Garrod, J.   Proposed integrated decision-tree testing strategies for mutagenicity and carcinogenicity in relation to the EU REACH legislation    ATLA, 35, 267-287 (2007)   [Abstract]    [PDF]

Combes, R.   Why 'Suitable' in vitro methods, as defined in the final EU REACH legislation, are an inappropriate basis for risk assessment    ATLA, 35, 289-293 (2007)   [Abstract]    [PDF]

Combes, R.   Reproductive toxicity testing under the REACH system -time for a paradigm shift    ATLA, 35, 1-4 (2007)   [Abstract]    [PDF]

Combes, R. and Balls, M.   Comments on the sub-group reports of the EU Technical Expert Working Group on the revision of Directive 86/609/EEC on the protection of animals used for experimental and other scientific purposes.    ATLA, 35, 155-175 (2007)   [Abstract]    [PDF]

Clothier, R.H.   Phototoxicity and Acute Toxicity Studies Conducted by the FRAME Alternatives Laboratory: A Brief Review    ATLA 35, 515-519 (2007)   [Abstract]    [PDF]

Boonsong, T., Norton, L., Chokkalingam, K., Jewell, K., Macdonald, I., Bennett, A. and Tsintzas, K.   Effect of exercise and and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and AKt signalling pathways    Biochemical Society Transactions, 35, 1310-1311 (2007)   [Abstract]   [Available from publisher]

Bhogal, N.   Testing new pharmaceuticals after the 2006 UK drug trail tragedy.    European Journal of Hospital Pharmacy Practice, 13, 22-24 (2007)   [Abstract]   [Available from publisher]

Bhogal, N.   After TGN1412: the CHMP draft guidelines    Hosptial Pharmacy Europe, 33, 43-44 (2007)   [Abstract]   [Purchase from publisher]

Bhogal, N. and Combes, R.   Immunostimulatory antibodies: Challenging the drug testing paradigm.    Toxicology in Vitro, 21, 1227-1232 (2007)   [Abstract]   [Purchase from publisher]

Balls, M.   Time for Real action on Chimpanzees and other Hominids    ATLA, 35, 191-195 (2007)   [Abstract]    [PDF]

Balls, M.   Richard Clothier: an appreciation    ATLA, 35, 531-537 (2007)   [Abstract]    [PDF]

Balls, M.   Animal experimentation and the Three Rs: why truth matters    ATLA, 35, 451-452 (2007)   [Abstract]    [PDF]

Balls, M.   Animal experimentation and the Three Rs: the need for hard heads and soft hearts and the need to confront the Three "I"s.    ATLA, 35, 547-548 (2007)   [Abstract]    [PDF]

Balls, M. and Combes, R.   Putting replacement first    ATLA, 35, 297-298 (2007)   [Abstract]    [PDF]

Athanasiou, A.., Clarke, A.B., Turner, A.E., Kumaran, N.M., Vakilpour,S., Smith, P.A., Bagiokou,D., Bradshaw, T.D., Westwell, A.D., Fang, L., Lobo, D..N., Constantinescu, C.S., Calabrese,V., Loesch, A., Alexander, S.P.H., Clothier, R.H., Kendall, D.A. and . Bates, T.E   Cannabinoid receptor agonists are mitochondrial inhibitors: A unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death    Biochemical and Biophysical Research Communications, 364, 131-137 (2007).   [Abstract]   [Purchase from publisher]

Seevaratnam, N., Bennett, A.J., Webber, J. and Macdonald, I.A.   The effects of underfeeding on whole-body carbohydrate partitioning, thermogenesis and uncoupling protein 3 expression in human skeletal muscle.    Dibaetes, Obesity & Metabolism, 9(5), 669-678 (2007)   [Abstract]   [Purchase from publisher]