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The Journal


Alternatives to Laboratory Animals - ATLA

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Papers List

List of papers, year 2000

Chen, J.J., Lin, K.K., Huque, M. and Arani, R.B.   Weighted p-value adjustments for animal carcinogenicity trend test.    Biometrics, 56(2), 586-592 (2000).   [Abstract]   [Purchase from publisher]

Cogley, T.P. and Cogley, M.C.   Use of detomidine hydrochloride as an adjunct for studying first-stage Gasterophilus intestinalis (Diptera : Gasterophilidae) in the tongue of the horse.    Veterinary Parasitology, 88(1-2), 159-161 (2000).   [Abstract]   [Purchase from publisher]

Corcoran, C., Mehta, C., Senchaudhuri, P.   Power comparisons for tests of trend in dose-response studies.    Statistics in Medicine, 19(22), 3037-3050 (2000).   [Abstract]   [Purchase from publisher]

de Lange, E.C.M., de Boer, A.G. and Breimer, D.D.   Methodological issues in microdialysis sampling for pharmacokinetic studies.    Advanced Drug Delivery Reviews, 45(2-3), 125-148 (2000).   [Abstract]   [Purchase from publisher]

Doxiadis, G.G.M., Otting, N., de Groot, N.G., Noort, R. and Bontrop, R.E.   Unprecedented polymorphism of Mhc-DRB region configurations in rhesus macaques.    Journal of Immunology, 165(4), 3193-3199 (2000).   [Abstract]   [Available from publisher]

Dunson, D.B., Haseman, J.K., van Birgelen, Apjm Stasiewicz, S. and Tennant, R.W.   Statistical analysis of skin tumor data from TgAC mouse bioassays.    Toxicological Sciences, 55(2), 293-302 (2000).   [Abstract]   [pdf]

Dunson, D.B. and Dinse, G.E.   Distinguishing effects on tumor multiplicity and growth rate in chemoprevention experiments.    Biometrics, 56(4), 1068-1075 (2000).   [Abstract]   [Purchase from publisher]

Dunson, D.B.   Assessing overall risk in reproductive experiments.    Risk Analysis, 20(4), 429-437 (2000).   [Abstract]   [Purchase from publisher]

Estill, S.J. and Garcia, J.A.   Marker assisted selection protocol (MASP) to generate C57BL/6J or 129S6/SvEvTac speed congenic or consomic strains.    Genesis, 28(3-4), 164-166 (2000).   [Abstract]   [Purchase from publisher]

Francis, K.P., Joh, D., Bellinger-Kawahara, C., Hawkinson, M.J., Purchio, T.F. and Contag, P.R.   Monitoring bioluminescent Staphylococcus aureus infections in living mice using a novel luxABCDE construct.    Infection and Immunity, 68(6), 3594-3600 (2000).   [Abstract]   [pdf]

Gorska, P.   Principles in laboratory animal research for experimental purposes.    Medical Science Monitor, 6(1), 171-180 (2000).   [Abstract]   [available from publisher]

Hagan, J.J., Harper, A.J., Elliott, H., Jones, D.N.C. and Rogers, D.C.   Practical and theoretical issues in gene-targeting studies and their application to behaviour.    Reviews in the Neurosciences, 11(1), 3-13 (2000).   [Abstract]   [purchase from publisher]

Harkin, A., Kelly, J.P., Frawley, J., O'Donnell, J.M. and Leonard, B.E.   Test conditions influence the response to a drug challenge in rodents.    Pharmacology Biochemistry and Behavior, 65(3), 389-398 (2000).   [Abstract]   [Purchase from publisher]

Hirst, R.A., Rutman, A., Sikand, K., Andrew, P.W., Mitchell, T.J. and O'Callaghan, C.   Effect of pneumolysin on rat brain ciliary function: Comparison of brain slices with cultured ependymal cells.    Pediatric Research, 47(3), 381-384 (2000).   [Abstract]   [Article in HTML]

Hunder, G., Javdani, J., Elsenhans, B. and Schumann, K.   Use of gamma-spectrometry for simultaneous determination of Pb-210, As-73, Cd-109, Hg-203 and Fe-59 distribution and excretion in rats at low doses.    Toxicology, 150(1-3), 69-82 (2000).   [Abstract]   [Purchase from publisher]

Kim, B.S., Cho, M.H. and Kim, H.J.   Statistical analysis of in vivo rodent micronucleus assay.    Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 469(2), 233-241 (2000).   [Abstract]   [Purchase from publisher]

Kodell, R.L., Lin, K.K., Thorn, B.T. and Chen, J.J.   Bioassays of shortened duration for drugs: Statistical implications.    Toxicological Sciences, 55(2), 415-432 (2000).   [Abstract]   [pdf]

Koek, W., Assie, M.B., Zernig, G. and France, C.P.   In vivo estimates of efficacy at 5-HT1A receptors: effects of EEDQ on the ability of agonists to produce lower-lip retraction in rats.    Psychopharmacology, 149(4), 377-387 (2000).   [Abstract]   [Purchase from publisher]

Lin, K.K.   Progress report on the guidance for industry for statistical aspects of the design, analysis, and interpretation of chronic rodent carcinogenicity studies of pharmaceuticals.    Journal Of Biopharmaceutical Statistics, 10(4), 481-501 (2000).   [Abstract]   [Purchase from publisher]

Lovell, D.P., Yoshimura, I., Hothorn, L.A., Margolin, B.H. and Soper, K.   Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999.    Environmental and Molecular Mutagenesis, 35(3), 260-263 (2000).   [Abstract]   [Purchase from publisher]

Lovell, D.P.   Dose-response and threshold-mediated mechanisms in mutagenesis: statistical models and study design.    Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 464(1), 87-95 (2000).   [Abstract]   [Purchase from publisher]

Miller, R.A. and Nadon, N.L.   Principles of animal use for gerontological research.    Journals of Gerontology Series a-Biological Sciences and Medical Sciences, 55(3), B117-B123 (2000).   [Abstract]   [Purchase from publisher]

Obrink, K.J. and Rehbinder, C.   Animal definition: a necessity for the validity of animal experiments?    Laboratory Animals, 34(2), 121-130 (2000).   [Abstract]   [pdf]

O'Driscoll, S.W. and Fitzsimmons, J.S.   The importance of procedure specific training in harvesting periosteum for chondrogenesis.    Clinical Orthopaedics and Related Research, November, 269-278 (2000).   [Abstract]   [Purchase from publisher]

Rawlings, C.A., Van Lue, S., King, C., Freeman, L., Damian, R.T., Greenacre, C., Chernosky, A., Mohamed, F.M. and Chou, T.M.   Serial laparoscopic biopsies of liver and spleen from Schistosoma-infected baboons (Papio spp.).    Comparative Medicine, 50(5), 551-555 (2000).   [Abstract]   [pdf]

Reinhardt, V. and Reinhardt, A.   The lower row monkey cage: an overlooked variable in biomedical research.    Journal of Applied Animal Welfare Science, 3(2), 141-149 (2000).   [Abstract]

Rittenhouse, K.D. and Pollack, G.M.   Microdialysis and drug delivery to the eye.    Advanced Drug Delivery Reviews, 45(2-3), 229-241 (2000).   [Abstract]   [Purchase from publisher]

Spindler, P., van der Laan, J.W., Ceuppens, P., Harling, R., Ettlin, R. and Lima, B.S.   Carcinogenicity testing of pharmaceuticals in the European Union: A workshop report.    Drug Information Journal, 34(3), 821-828 (2000).   [Abstract]   [available from publisher]

Takizawa, T., Igarashi, T., Imamizo, H., Ikeda, T., Omichi, K., Kadota, T., Kawata, M., Sakaki, H., Terai, H., Tsukamoto, O., Totsuka, K., Handa, J., Hirata, A., Mizuma, H., Murakami, Y., Yamada, M. and Yokouchi, H.   A study on the consistency between flagging by statistical tests and biological evaluation.    Drug Information Journal, 34(2), 501-509 (2000).   [Abstract]   [Article in HTML]

Verweij, B.H., Muizelaar, J.P., Vinas, F.C., Peterson, P.L., Xiong, Y. and Lee, C.P.   Improvement in mitochondrial dysfunction as a new surrogate efficiency measure for preclinical trials: dose-response and time-window profiles for administration of the calcium channel blocker Ziconotide in experimental brain injury.    Journal of Neurosurgery, 93(5), 829-834 (2000).   [Abstract]   [purchase from publisher]

Broadhead, C.L., Betton, G., Combes,R. Damment, S., Everett, D., Garner, C., Godsafe, Z., Healing, G., Heywood, R., Jennings, M., Lumley, C., Oliver, G., Smith, D., Straughan, D., Topham, J., Wallis,R., Wilson,S., and Buckley, P.   Prospects for reducing and refining the use of dogs in the regulatory toxicity testing of pharmaceuticals.    Human and Experimental Toxicology, 19(8), 440-447 (2000).   [Abstract]   [Purchase from publisher]

Jenkins, E.S. and Combes, R.D.   The application of microarray technology to reduce, refine and replace animals in research.    Toxicology Letters, 116(Suppl. 1), 100 (2000).   [Abstract]   [Purchase from publisher]

Garle, M.J., Knight, A., Downing, A.T., Jassi, K.L., Clothier, R.H. and Fry, J.R.    Stimulation of dichlorofluorescin oxidation by capsaicin and analogues in RAW 264 monocyte/macrophages: lack of involvement of the vanilloid receptor.    Biochemical Pharmacology, 59(5), 563-572 (2000).   [Abstract]   [Purchase from publisher]

Combes, R.D.   The use of structure–activity relationships and markers of cell toxicity to detect non-genotoxic carcinogens.    Toxicology in Vitro, 14(4), 387-399 (2000).   [Abstract]   [Purchase from publisher]

Broadhead, C.L. and Smith, D.   A proposal to evaluate approaches to reduce and refine dog studies in preclinical toxicology.    Toxicology Letters, 116(Suppl. 1), 60 (2000).   [Abstract]   [Purchase from publisher]

Balls, M.   Drunken monkeys and cruel humans.    ATLA, 28, 639–640 (2000).   [Abstract]    [PDF]

Balls, M. and Combes, R.   Promoting the three Rs: actions speak louder than words.    ATLA, 28, 741–742 (2000).   [Abstract]    [PDF]

Benford, D.J., Hanley, A.B., Bottrill, K., Oehlschlager, S., Balls, M., Branca, F., Jaques Castegnaro, J., Descotes, J., Hemminiki, K., Lindsay, D. and Schilter, B.   Biomarkers as predictive tools in toxicity testing the report and recommendations of ECVAM Workshop 40.    ATLA, 28, 119–131 (2000).   [Abstract]    [PDF]

Clothier, R., Orme, A., Walker, T.L., Ward, S.L., Kruszewski, F.H., DiPasquale, L.C. and Broadhead, C.L.   A comparison of three cytotoxicity endpoints in the corneal HCE-T model.    ATLA, 28, 293–302 (2000).   [Abstract]    [PDF]

Combes, R.D.   Endocrine disruptors: A critical review of in vitro and in vivo testing strategies for assessing their toxic hazard to humans.    ATLA, 28, 81–118 (2000).   [Abstract]    [PDF]

Jenkins, E.S. and Combes, R.D.   FRAME’s response to an APC questionnaire on emerging biotechnologies and The Animals (Scientific Procedures) Act 1986.    ATLA, 28, 333–338 (2000).   [Abstract]    [PDF]