Papers List

Garle,M.J., Sinclair, C., Thurley P. and Fry, J.R.    Haloalcohols deplete glutathione when incubated with fortified liver fractions.    Xenobiotica, 29(5), 533 - 545 (1999).   [Abstract]   [Purchase from publisher]

Combes, R.D. and Earl, L.K.   BTS special symposium. In vitro toxicology - priorities for the year 2000. University of Surrey, 23 April 1998. Report of a symposium to discuss the BTS working party report on in vitro toxicology.    Human & Experimental Toxicology, 18(2), 126-136 (1999).   [Abstract]   [Purchase from publisher]

Hammond, A.H., Garle, M.J. and Fry, J.R.   The nature of halogen substitution determines the mode of cytotoxicity of halopropanols.    Toxicology and Applied Pharmacology, 155(3), 287-291 (1999).   [Abstract]   [Purchase from publisher]

Hammond, A.H. and Fry, J.R.   Effect of cyanamide on toxicity and glutathione depletion in rat hepatocyte cultures: differences between two dichloropropanol isomers.    Chemico-Biological Interactions, 122(2), 107-115 (1999).   [Abstract]   [Purchase from publisher]

Gray, A.C., Garle, M.J. and Clothier, R.H.   Fluorescein cadaverine incorporation as a novel technique for the characterization of terminal differentiation in keratinocytes.    Toxicology in Vitro, 13(4-5), 773-778 (1999).   [Abstract]   [Purchase from publisher]

DeJongh, J., Forsby, A., Houston, J.B., Beckman, M., Combes, R. and Blaauboer, B.J.   An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological In vitro test methods: overview of a prevalidation study based on the ECITTS project.    Toxicology in Vitro, 13(4-5), 549-554 (1999).   [Abstract]   [Purchase from publisher]

Zanvit, A., Meunier, P-A., Clothier, R., Ward, R., and Buiatti-Tcheng, M.   Ocular irritancy assessment of cosmetics formulations and ingredients: fluorescein leakage test.    Toxicology in Vitro, 13(2), 385-391 (1999).   [Abstract]   [Purchase from publisher]

Combes, R.D.   Summary of discussion: in vitro models for investigation of chronic toxicity and reversibility.    Toxicology in Vitro, 13(4-5), 853-857 (1999).   [Abstract]   [Purchase from publisher]

Clothier, R., Starzec, G., Stipho, S. and Kwong, Y.C.    Assessment of initial damage and recovery following exposure of MDCK cells to an irritant.    Toxicology in Vitro, 13(4-5), 713-717 (1999).   [Abstract]   [Purchase from publisher]

Bull, S., Catalani, P., Garle, M., Coecke. S. and Clothier, R.    Imipramine for cytochrome P450 activity determination: a multiple-species metabolic probe.    Toxicology in Vitro, 13(4-5), 537-541 (1999),   [Abstract]   [Purchase from publisher]

Budworth, R.A., Anderson, M., Clothier, R.H. and Leach, L.   Histamine-induced changes in the actin cytoskeleton of the human microvascular endothelial cell line HMEC-1.    Toxicology in Vitro, 13(4-5), 789-795 (1999).   [Abstract]   [Purchase from publisher]

Bigota, K., de Lange, J., Archer, G., Clothier, R. and Bremer, S.    The relative semi-quantification of mRNA expression as a useful toxicological endpoint for the identification of embryotoxic/teratogenic substances.    Toxicology in Vitro, 13(4-5), 619-623 (1999).   [Abstract]   [Purchase from publisher]

Balls, M.   The precautionary principle should be used with caution -and should be applied to animal experimentation and genetic manipulation, not merely to protection of the environment.    ATLA, 27(1), 1-5 (1999).   [Abstract]    [PDF]

Balls, M.   Animal experiments: letting the people speak.    ATLA, 27, 503–504 (1999)   [Abstract]    [PDF]

Balls, M.   Does the use of transgenic animals raise particular welfare and ethical concerns?    ATLA, 27(Suppl. 1), 811–813 (1999).   [Abstract]    [PDF]

Bottrill, K.   Seeking information on the three Rs - more than just a legal burden.    ATLA, 27, 215-218 (1999).   [Abstract]    [PDF]

Clothier, R., Willshaw, A.,Cox, H., Garle, M., Bowler, H. and Combes, R.   The use of human keratinocytes in the EU/COLIPA international in vitro phototoxicity test validation study and the ECVAM/COLIPA study on UV filter chemicals.    ATLA, 27, 247-259 (1999).   [Abstract]    [PDF]

Coecke, S., Rogiers, V., Bayliss, M., Castell, J., Doehmer, J., Fabre, G., Fry, J., Kern, A. and Westmoreland, C.   The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes: the current status ECVAM hepatocytes and metabolically competent systems task force report.    ATLA, 27, 579-638 (1999).   [Abstract]    [PDF]

Combes, R.D. and Balls, M.   Precautions and claims for “safety” based on inadequate risk assessment are hazardous and expose all concerned to risk.    ATLA, 27, 903-906, (1999).   [Abstract]    [PDF]

Combes, R., Balls, M., Curren, R., Fischbach, M., Fusenig, N., Kirkland, D., Lasne, C., Landolph, J., LeBoeuf, R., Marquardt, H., McCormick, J., Müller, L., Rivedal, E., Sabbioni, E., Tanaka, N., Vasseur, P. and Yamasaki, H.   Cell transformation assays as predictors of human carcinogenicity: the report and recommendations of ECVAM Workshop 39.    ATLA, 27, 745-767 (1999).   [Abstract]    [PDF]

Cooper-Hannan, R., Harbell, J.W., Coecke, S., Balls, M., Bowe, G., Cervinka, M., Clothier, R., Hermann, F., Klahm, L.K., de Lange, J., Liebsch, M. and Vanparys, P.   The principles of good laboratory practice: application to in vitro toxicology studies the report and recommendations of ECVAM Workshop 37.    ATLA, 27, 539-577 (1999).   [Abstract]    [PDF]

Elton, R.C., Rhodes, P. and Fry, J.R.   Evaluation of a short-term rat proximal tubule incubation system for the detection of nephrotoxicants.    ATLA, 27, 433-448 (1999).   [Abstract]    [PDF]

Gray, S.J.   Cats in scientific procedures: main areas of use in the UK and some causes for concern.    ATLA, 27, 153-160 (1999).   [Abstract]    [PDF]

Hammond, A.H., Garle, M.J. and Fry, J.R.   A preliminary comparison of LiverBeadsTM with a conventional rat hepatocyte culture preparation: some aspects of xenobiotic metabolism and related toxicity.    ATLA, 27, 111-119 (1999).   [Abstract]    [PDF]

Jenkins, E.S. and Combes, R.D.   Transgenic models for prion disease: have they outlived their useful purpose?    ATLA, 27, 827–838 (1999).   [Abstract]    [PDF]

Jenkins, E.S. and Francis, R.F.   New guidance notes for projects generating or maintaining genetically modified animals.    ATLA, 27, 883–902 (1999).   [Abstract]    [PDF]

Langley, G., Broadhead, C., Bottrill, K., Combes, R., Ewbank, R., Hawkins, P., Hubrecht, R., Jennings, M., Newman, C., Rowe, S., JSouthee, J., Todd, M. and Ward, L.   Accessing information on the reduction, refinement and replacement of animal experiments report and recommendations of a Focus on Alternatives Workshop.    ATLA, 27, 239–245 (1999).   [Abstract]    [PDF]

van Zeller, A-M. and Combes, R.D.   Transgenic mouse bioassays for carcinogenicity testing: A step in the right direction?    ATLA, 27(Suppl. 1), 839–846 (1999).   [Abstract]    [PDF]

Wirachwong, P. and Fry, J.R.   Lack of effect of medium supplementation with pyruvate and hormones on cytochrome P450-mediated activity of rat hepatocytes in primary culture.    ATLA, 27, 283–288 (1999).   [Abstract]    [PDF]