Developing, validating and using test batteries and tired (hierarchical) testing schemes

Combes, R.

ATLA, 35, 375-378 (2007)

Replacement methods for toxicity prediction are often deployed: a) as part of a test battery; b) in a tiered (hierarchical) scheme; or c) in a combination of the two approaches. However, the development and validation of test batteries and tiered testing strategies is controversial — no test battery or tiered testing scheme has yet been formally validated.