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Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999.

Lovell, D.P., Yoshimura, I., Hothorn, L.A., Margolin, B.H. and Soper, K.

Environmental and Molecular Mutagenesis, 35(3), 260-263 (2000).

A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genoXtoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental unit to the experimental design, and the impact of new developments in statistics and computing. Three major recommendations were made relating to the need for: (1) the effective use of statistical advice in designing interlaboratory and statistical advice in designing interlaboratory and of appropriate experimental designs for new assays; and (3) education and training in the use of statistical methodology in mutagenicity testing.