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Elucidation of tumor-promoting potential of a combination pesticide by short-term, in vivo bioassay.


Murali M.E. Rajaram G.M., Amirtha G.D., Banu P.C.A.Y., Arun S.L.A., Amalan S.V., Sadasivan P.K. and Balakrishnamurthy, P.

Journal of Environmental Pathology, Toxicology and Oncology, 20(3), 155-164 (2001).

The use of combination pesticide (profenofos 40% + cypermethrin 4% EC) is on the rise in India and elsewhere. Cypermethrin is reported to be a tumor promoter, but its tumor-promoting potential along with profenofos is yet to be studied. A short-term, in vivo test for detection of a tumor promoter is cost-effective, saves time, and requires fewer animals than conventional methods. We report on a short-term test based on mechanisms of significant importance in tumor promotion. In this study, we have tested the tumor-promoting potential of a combination pesticide containing profenofos 40% and cypermethrin 4% EC in Wistar rats. Although cypermethrin has been reported as a tumor promoter, our study shows that the combination pesticide containing profenofos 40% and cypermethrin 4% EC is not a tumor promoter.