An analysis of ISO intracutaneous reactivity test results to justify a reduction in animal requirements.
Upman, P.J., Anderson, J. and Tasse, L.
Lab Animal, 32(3), 26-27 (2003).
The ISO intracutaneous reactivity test is the standard protocol for determining a medical device's potential for causing irritation. The authors present data indicating that the number of animals required per test can be reduced from three rabbits to two.