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An analysis of ISO intracutaneous reactivity test results to justify a reduction in animal requirements.

Upman, P.J., Anderson, J. and Tasse, L.

Lab Animal, 32(3), 26-27 (2003).

The ISO intracutaneous reactivity test is the standard protocol for determining a medical device's potential for causing irritation. The authors present data indicating that the number of animals required per test can be reduced from three rabbits to two.