Home banner
Divider
A-Z Index

Quick way to the find the information that you need...

More button
Register with FRAME

Although you do not need to register, any information you provide will be confidential and used only by FRAME to improve the website

Register button
Account Login
Forgot password?

ATLA - ISI
The Journal

 

Alternatives to Laboratory Animals - ATLA

Download latest issue button Download back issues button Subscribe to ATLA
Contact Us

Tel icon

Tel: +44 (0)115 9584740


Tel icon

Fax: +44 (0)115 9503570

Make an Enquiry

Reducing the number of animals used in behavioural genetic experiments using chromosome substitution strains.


Laarakker, M. C., Ohl, F. and van Lith, H. A.

Animal Welfare, 15(1), 49-54 (2006)

Chromosome substitution strains (also called consomic lines or strains) are strains in which a single, full-length chromosome from one inbred strain - the donor strain - has been transferred onto the genetic background of a second inbred strain - the host strain. Based on the results obtained from behavioural tests with the two parental strains, the minimum number of animals from each of the host and consomic strains that are required for a successful behavioural genetic analysis can be estimated. Correct application of statistical knowledge can lead to a further reduction in the number of animals used in behavioural genetic experiments using chromosome substitution strains.