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Alternatives to Laboratory Animals - ATLA

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Monoclonal antibody production the report and recommendations of ECVAM Workshop 23.

Marx, U., Embleton, M.J., Fischer, R., Gruber, F.P., Hansson, U., Heuer, J., de Leeuw, W.A., Logtenberg, T., Merz, W., Portetelle, D., Romette, J-L. and Straughan, D.W.

ATLA, 25(2), 121-137 (1997).

This is the report of the twenty-third of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The workshop on Monoclonal Antibody Production was held in Angera, Italy, on 19–22 November 1996, under the chairmanship of Uwe Marx (University of Leipzig, Germany). The aim of the workshop was to evaluate the present status of in vitro methods for monoclonal antibody (mAb) production, and to compare the advantages and disadvantages of the in vitro methods with those of the traditional in vivo (malignant ascites) method.