The links on the left guide you through the main regulatory organisations and how they have implemented the use of reduction, refinement or replacement alternative methods for testing chemicals, drugs and medical devices. These are:
The Organisation for Economic Cooperation and Development (OECD) develops test guidelines that assist with the safety and toxicity testing of chemicals and substances.
The International Organisation for Standardisation (ISO) provides information and guidance for risk assessment and includes material of specific relevance to the risk assessment for medical and dental devices.
The International Conference on Harmonisation (ICH) provides guidelines and a list of technical requirements for the registration of human medicines and brings together the regulatory authorities of Europe, Japan and the United States as well as pharmaceutical industry experts to discuss scientific and technical aspects of medicines registration.