The History of FRAME
The Early Years - FRAME was founded in London in 1969 by Dorothy Hegarty who was introduced to the Three Rs by the biologist Charles Foister. The main aim of FRAME has always been to promote the Three Rs as a way forward for animal experimentation. It was registered as a UK charity.
1978 - Royal Society symposium on the Use of Alternatives in Drug Research. One participant, Dr Michael Balls, a zoologist from the University of Nottingham, later became a FRAME trustee
1979 - The first FRAME Toxicity Committee established.
1981 - Michael Balls became Chairman of the FRAME trustees and FRAME moved to Nottingham.
1983 - With the help of funding from the Maurice Laing Foundation, ATLA, formerly a pamphlet style publication, was relaunched as a peer-reviewed international scientific journal.
Go to ATLA home page
1983 - FRAME acts as advisor to the government, along with the British Veterinary Association (BVA) and the Committee for the Reform of Animal Experimentation (CRAE) to advise the government on the Animals (Scientific Procedures) Act. This act came into force in 1986.
1984 - FRAME receives first ever government grant to research replacement methods1986 - FRAME received the first Marchig Animal Welfare Award from the World Society for the Protection of Animals (WSPA).
1989 - INVITTOX database, a collection of protocols for in vitro methods in toxicology, was established. This database is now part of ECVAM's Scientific Information Service.
1991- the FRAME Alternatives Laboratory (FAL) opened. It is still conducting research into alternatives at the University of Nottingham Medical School. FRAME provides a block grant every year to sustain the research.
1995- The FRAME office relocated to the newly built Russell & Burch House, Nottingham.
1998- FRAME became a founder member of Focus on Alternatives. This represented a significant step to promote dialogue between all UK groups that focus on replacement alternatives.
1999- First annual FRAME lecture delivered by Bill Russell.
2000-2003 - EU regulators accepted the first three replacement alternatives to animal-based toxicity testing. One of these, a phototoxicity test, had been validated in a 1997 study that involved the FAL.
Present day – FRAME continues to promote the Three Rs to the public, academia and industry.