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Facelifts, baldness and botulinum toxin (aka Botox)

FRAME is deeply concerned about the use of botulinum toxin (like botox) for cosmetic purposes, and the apparent indifference by its users to the intense animal suffering its production causes.  There is no excuse for animals being subjected to painful and distressing procedures for the sake of human vanity.

FRAME was delighted when a new, non-animal test was developed for establishing the strength of batches of botulinum toxin.  See here for additional information.


FRAME believes batches of botulinum toxin should be tested according to the purpose for which they will be used so that those intended for cosmetic use cannot be tested on animals. All trivial, non-medical uses of botulinum toxin should be stopped until it can be tested by humane methods.


Additional information


The toxin, sometimes known as botox, is used for anti-wrinkle treatments and facelifts and has been suggested as a baldness cure.


The toxin is produced by bacteria, but, since it its strength varies, each new batch has to be tested separately, to determine its potency and its toxicity. It is tested on mice, which are dosed until they are paralysed and half of them die. There is currently no accepted non-animal, test to protect the safety of people receiving the treatment although there is a more humane one that ends when the mouse’s body goes limp, rather than full paralysis.


There are important medical reasons for the use of botulinum toxin such as treating squints and some forms of cerebral palsy, so some needs to be produced for those reasons. UK law prevents animal tests on cosmetic products but botulinum procedures are invasive and performed by a doctor, so they are classed as surgery and the toxin is tested as a medicine.


The most disturbing test involves injecting hundreds of mice with the toxin to find the dose that kills half of them (known as the LD50 test). It causes the animals to suffocate slowly to death because their diaphragm is paralysed.


Death continues to be used by some manufacturers as the way the activity of batches is estimated. In the UK a non-lethal test is used instead. It might also be possible to humanely kill the animals at a much earlier time to reduce their suffering.


Cosmetic use of botulinum toxin represents a considerable proportion of the total amount of botulinum toxin used worldwide. It contributes to vast numbers of mice being used for botulinum testing.