Recent FRAME publications

2010

Balls, M. (2010). Adult stem cells and toxicity testing: Realising the potential. ATLA 38, 91–92.

Balls, M. (2010). Alternative methods: Servants of two masters. ATLA 38, 195–197.

Balls, M. (2010). Integrated testing strategies and the prediction of toxic hazard. In In Silico Toxicology (ed.
M.T.D. Cronin & J.C. Madden), pp. 584–605. Cambridge, UK: The Royal Society of Chemistry.

Balls, M. (2010). ATLA (Alternatives to Laboratory Animals): Past, present and future. ATLA 38, 437–441.

Balls, M. (2011). Replacing animal experimentation: On creating the puzzles to be solved. ATLA 39, 1–2.

Balls, M. & Clothier, R. (2010). A FRAME response to the European Commission Consultation on the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects — 2010. ATLA 38, 345–353.

Balls, M. & Morton, D. (2010). FRAME and the Three Rs: Yesterday, today and tomorrow. ATLA 38, 269–274.

Bennett, A. (2010). The use of human tissues and cells in biomedical research: The unusual suspects. ATLA 38, Suppl. 1, 5–9.

Bhogal, N. (2010). EPAA Workshop and 2009 Annual Conference: Dissemination of 3Rs Information. [Conference Report] ATLA 38, 249–251.

Bhogal, N. (2010). The European Society for Animal Cell Technology 20th Annual Meeting. [Conference Report] ATLA 38, 252–253.

Bhogal, N. (2010). The In Vitro Testing Industrial Platform: Toxicology in the 21st Century — Working our way toward a visionary reality. [Conference
Report] ATLA 38, 254–256.

Bhogal, N. (2010). Introduction to the FRAME 40th Anniversary Symposium on Human Alternatives to Animal Studies. ATLA 38, Suppl. 1, i–ii.

Bhogal, N. (2010). A time to replace animal models? — A clinical perspective: Reflections on the keynote address. ATLA 38, Suppl. 1, iii–v.

Hudson, M. & Balls, M. (2010). European experimental animal use declines ever so slightly. ATLA 38, 529–532.

Seabra, R. & Bhogal, N. (2010). In vivo research using early life stage models. In Vivo 24,457–462.

Seabra, R. & Trigwell, S. (2010). ATLA — A truly international journal. ATLA 38, 259–260.

2009

Balls, M. (2009). Animal experiments and alternatives: Time to confront truth and uncertainty, and to combine idealism with realism. AATEX 14, 821–827.

BéruBé, K., Aufderheide, M., Breheny, D., Clothier, R., Combes, R., Duffin, R., Forbes, B., Gaça, M., Gray, A., Hall, I., Kelly, M., Lethem, M., Liebsch, M., Merolla, L., Morin, J-P., Seagrave, J.C., Swartz, M.A., Tetley, T.D. & Umachandran, M. (2009). In vitro models of inhalation toxicity and disease. The Report of a FRAME Workshop. ATLA 37, 89–141.

Gaines Das, R., Fry, D., Preziosi, R. & Hudson, M. (2009). Planning for reduction. ATLA 37, 27–32.

Howard, B., Hudson, M. & Preziosi, R. (2009). More is less: reducing animal use by raising awareness of the principles of efficient study design and analysis. ATLA 37, 33–42.

Hudson, M. & Howard, B. (2009). The FRAME Reduction Steering Committee: reflections on a decade devoted to reducing animal use in biomedical science. ATLA 37, 23–26.

Seabra, R. & Bhogal, N. (2008). Hospital infections, animal models and alternatives. European Journal of Clinical Microbiology & Infectious Diseases 28, 561–568.

2008

Bhogal, N., Combes, R. & Balls, M. (2008). Preclinical drug development planning. In Preclinical Development Handbook (ed. S.C. Gad), pp. 1–64. Hoboken, NJ, USA: John Wiley & Sons, Inc.

Combes, R., Grindon, C., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2008). Integrated decision-tree testing strategies for acute systemic toxicity and toxicokinetics with respect to the requirements of the EU REACH legislation. ATLA 36, 45–63.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2008). Integrated decision-tree testing strategies for developmental and reproductive toxicity with respect to the requirements of the EU REACH legislation. ATLA 36, 65–80.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2008). An integrated decision-tree testing strategy for eye irritation with respect to the requirements of the EU REACH legislation. ATLA 36, 81–92.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2008). An integrated decision-tree testing strategy for repeat dose toxicity with respect to the requirements of the EU REACH legislation. ATLA 36, 93–101.

Helguera, A.M., Cordeiro, M.N.D.S., Pérez, M.A.C., Combes, R.D. & González, M.P. (2008). QSAR modeling of the rodent carcinogenicity of nitrocompounds. Bioorganic & Medicinal Chemistry 16, 3395–3407.

Hudson, M. (2008). The Home Office Statistics for 2007 - Mutant Mice and Fishy Tales. ATLA 36, 695-704.

2007

Athanasiou, A., Clarke, A.B., Turner, A.E., Kumaran, N.M., Vakilpour, S., Smith, P.A., Bagiokou, D., Bradshaw, T.D., Westwell, A.D., Fang, L., Lobo, D.N., Constantinescu, C.S., Calabrese, V., Loesch, A., Alexander, S.P., Clothier, R.H., Kendall, D.A. & Bates, T.E. (2007). Cannabinoid receptor agonists are mitochondrial inhibitors: A unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical & Biophysical Research Communications 364, 131–137.

Balls, M. (2007). Animal experimentation and the Three Rs: why truth matters. ATLA 35, 451–452.

Balls, M. (2007). Animal experimentation and the Three Rs: the need for hard heads and soft hearts and the need to confront the Three "I"s. ATLA 35, 547–548.

Balls, M. (2007). Richard Clothier: an appreciation. ATLA 35, 531–537.

Bhogal, N. & Combes, R. (2007). Immunostimulatory antibodies: Challenging the drug testing paradigm. Toxicology in Vitro 21, 1227–1232.

Boonsong, T., Norton, L., Chokkalingam, K., Jewell, K., Macdonald, I., Bennett, A. & Tsintzas, K. (2007). Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways. Biochemical Society Transactions 35, 1310–1311.

Clothier, R.H. (2007). Phototoxicity and acute toxicity studies conducted by the FRAME Alternatives Laboratory: a brief review. ATLA 35, 515–519.

Combes, R.D. (2007). The FRAME Research Programme under the direction of Dr Richard Clothier. ATLA 35, 525–530.

Combes, R.D. (2007). Alternatives to animal testing. In Comprehensive Medicinal Chemistry II Volume 1 (ed. D.J. Triggle & J.B. Taylor), pp 463–487. Oxford, UK: Elsevier.

Constantin, D., Constantin-Teodosiu, D., Layfield, R., Tsintzas, K., Bennett, A.J. & Greenhaff, P.L. (2007). PPAR delta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle. Journal of Physiology 583, 381–390.

Erhuma, A., Bellinger, L., Langley-Evans, S.C. & Bennett, A.J. (2007). Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the rat. The British Journal of Nutrition 98, 517–524.

Erhuma, A., Salter, A.M., Sculley, D.V., Langley-Evans, S.C. & Bennett, A.J. (2007). Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat. American Journal of Physiology. Endocrinology & Metabolism 292, E1702–E1714.

Gray, A.C., McLeod, J.D. & Clothier, R.H. (2007). A review of in vitro modelling approaches to the identification and modulation of squamous metaplasia in the human tracheobronchial epithelium. ATLA 35, 493–504.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2007). Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation. ATLA 35, 673–682.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2007). An integrated decision-tree testing strategy for skin sensitisation with respect to the requirements of the EU REACH legislation. ATLA 35, 683–697.

Hurst, H.S., Clothier, R.H. & Pratten, M. (2007). An evaluation of a novel chick cardiomyocyte micromass culture assay with two teratogens/embryotoxins associated with heart defects. ATLA 35, 505–514.

Khammo, N., Ogilvie, J. & Clothier, R.H. (2007). Development of an innervated model of human skin. ATLA 35, 487–491.

Kinsner-Ovaskainen, A., Clemedson, C., Cole, T., Clothier, R., Coecke, S., O’Connor, J-E., Blaauboer, B., Gómez-Lechón, M-J., Vericat, J-A., Forsby, A., Ryan, M.P., Castell, J., Risteli, L. & Wendel, A. (2007). Optimisation and pre-validation of an in vitro test strategy for predicting human acute toxicity: Progress of the "A-Cute-Tox" project. Toxicology Letters 172 Suppl. 1, S83.

Reid, L., Khammo, N. & Clothier, R.H. (2007). An evaluation of the effects of photoactivation of bithionol, amiodarone and chlorpromazine on human keratinocytes in vitro. ATLA 35, 471–485.

Ruben, L., Clothier, R.H. & Balls, M. (2007). Cancer resistance in amphibians. ATLA 35, 463–470.

Scrivens, M. & Bhogal, N. (2007). The use of human cell line reporter gene-based assays in chemical toxicology testing. Toxicology in Vitro 21, 1233–1240.

Seevaratnam, N., Bennett, A.J., Webber, J. & Macdonald, I.A. (2007). The effects of underfeeding on whole-body carbohydrate partitioning, thermogenesis and uncoupling protein 3 expression in human skeletal muscle. Diabetes, Obesity & Metabolism 9, 669–678.

Sun, Y., Alexander, S.P.H., Garle, M.J., Gibson, C.L., Hewitt, K., Murphy, S.P., Kendall, D.A. & Bennett, A.J. (2007). Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. British Journal of Pharmacology 152, 734–743.