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The Journal


Alternatives to Laboratory Animals - ATLA

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What FRAME does


 Skin test patches on a human back

FRAME's main aim is to find scientific methods that remove the need for animals in laboratories. They can be alternative research and testing methods such as cells in culture, computer-based approaches, the use of donated human cells and tissues, or studies on volunteers.

We look at ways to reduce the number of animals involved in experiments and how to refine systems to minimise the distress and pain that test animals undergo.

Laboratory research
FRAME supports laboratory research at the University of Nottingham, and some grants have been awarded to other scientists working on the development of non-animal methods.


Office research
FRAME scientists carry out desk-based research into a range of areas and investigate how to implement the Three Rs.


Political lobbying
We also campaign in a number of areas and lobby for changes in legislation, where appropriate.


Animal Statistics
At FRAME we analyse UK annual statistics and EU statistics on laboratory animal use to identify areas where Three Rs initiatives can be better applied. FRAME is concerned that animal experiments are persistently rising each year, largely due to the continuing use of genetically modified mice and an increased interest in investigations and tests in fish.


FRAME trains working animal scientists in methods that help them to use fewer animals and to extract more and better data from their experiments without the need to use more animals.