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The Journal


Alternatives to Laboratory Animals - ATLA

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New reduction strategic planning chart

Flow chartThe FRAME Reduction Steering Committee (FRSC) notes that many scientists have little formal training in the basic elements of experimental design and statistics. They also have difficulties in finding and retrieving useful training material on these subjects.


So the committee has developed a flow chart of an overall strategy for planning and conducting biomedical research. The strategy evolved because experiments using laboratory animals do not normally occur as isolated ‘one-off’ studies, and there is often considerable scope for decreasing overall severity and reducing the number of animals used by careful planning and design in the context of the complete programme. The Strategic Planning chart, effective training and good planning can improve scientific output, increase animal welfare and reduce animal use.


FRSC aims to reduce the number of animals used in research, education and testing without compromising the quality of research or hindering scientific progress. In working toward this goal the Committee advocates that good experimental design and the appropriate use of statistical tests are the corner-stone of high quality scientific research.


In order to raise awareness the FRSC conducts training schools that give participants an appreciation of factors to consider when designing experiments. They also teach the basic skills needed to design and analyse work to refine procedures and housing, minimise the number of animals used, and maximise the quality and relevance of the data obtained.

To download a copy click here

Or to obtain a printed copy to display in your lab email info@frame.org.uk

Archived Oct 8 2009