Throughout its history FRAME has promoted the Three Rs to the public, academia and industry.

2014 – Complete overhaul of FRAME’s public face including new websites, redesigned FRAME News and launch of the Timeline.

2013 – Review of dog use in drugs testing published in ATLA, reveals that use of dogs as second species is extremely unreliable.

2012- FRAME launches the PiLAS website (Perspectives in Laboratory Animal Science) to provide a platform for informal discussion of current challenges facing bio-scientists.

2010- FRAME takes part in European Commission Consultation on Alternative (Nonanimal) Methods for Cosmetics Testing.

2009 – FRAME’s 40th anniversary year marked by a series of events including seminars on 21st century drug development, and human alternatives to animal experimentation.

2000-2003 – EU regulators accepted the first three replacement alternatives to animal-based toxicity testing. One of these, a phototoxicity test, had been validated in a 1997 study that involved the FAL.

1999- First annual FRAME lecture delivered by Bill Russell.

1998-  FRAME became a founder member of Focus on Alternatives. This represented a significant step to promote dialogue between all UK groups that focus on replacement alternatives.

1995- The FRAME office relocated to the newly built Russell & Burch House, Nottingham.

1991- the FRAME Alternatives Laboratory (FAL) opened.  It is still conducting research into alternatives at the University of Nottingham Medical School. FRAME provides a block grant every year to sustain the research.

1989 -  INVITTOX database, a collection of protocols for in vitro methods in toxicology, was established. This database is now part of ECVAM’s Scientific Information Service.

1984 – FRAME receives first ever government grant to research replacement methods1986 – FRAME received the first Marchig Animal Welfare Award from the World Society for the Protection of Animals (WSPA).

1983 – FRAME acts as advisor to the government, along with  the British Veterinary Association (BVA) and the Committee for the Reform of Animal Experimentation (CRAE) to advise the government on the Animals (Scientific Procedures) Act. This act came into force in 1986.

1983 -  With the help of funding from the Maurice Laing Foundation, ATLA, formerly a pamphlet style publication, was relaunched as a peer-reviewed international scientific journal.

1981 -  FRAME moved to Nottingham.

1979 – The first FRAME Toxicity Committee established.

1978 – Royal Society symposium on the Use of Alternatives in Drug Research.

The Early Years – FRAME was founded  in London in 1969 by Dorothy Hegarty who was introduced to the Three Rs by the biologist Charles Foister.  The main aim of FRAME has always been to promote the Three Rs as a way forward for animal experimentation. It was registered as a UK charity.