FRAME is the Fund for the Replacement of Animals in Medical Experiments.

FRAME’s vision is a world where non-animal methods are accepted as scientific best practice.

Its Mission is to support the timely development and implementation of scientifically valid methods which will provide reliable data and replace the need for animal experiments.

FRAME is dedicated to the development of new and valid methods that will replace the need for laboratory animals in medical and scientific research, education, and testing. Where the use of animals is currently necessary, FRAME supports the reduction of numbers involved to an unavoidable minimum and refinement of experimental procedures to minimise any suffering caused.

FRAME believes that the current scale of animal experimentation is unacceptable, but recognises that the immediate abolition of all laboratory animal use is not possible.

FRAME promotes the elimination of the need to use laboratory animals through various activities including campaigning, publication of a scientific journal, office-based and laboratory research.

FRAME was founded in London in 1969 by Dorothy Hegarty. The main aim of FRAME has always been to promote the Three Rs (Replacement, Reduction & Refinement) as a way forward for animal experimentation. It was registered as a UK charity.

FRAME supports a laboratory at the University of Nottingham where non-animal models and techniques are developed.

FRAME was one of the three organisations who advised the UK Government on introduction of the Animals (Scientific Procedures) Act 1986.