Timeline

2013 – Cosmetics testing on animals banned in EU

March 2013 saw the European Union pass a full ban on the sale of any and all cosmetic products that had been tested on animals. This was the result of over a decade’s work from alternatives organizations and governments in cooperation with cosmetics companies to prevent the distribution of unregulated and unethical products. This highlights […]

May 27th, 2014|Timeline, TL_legislation|Comments Off

2010 – Organ-on-a-chip technology introduced

One of the most substantial modern breakthroughs in alternatives research came from the Wyss Institute for Biologically Inspired Engineering at Harvard University in the form of the ‘organ-on-a-chip’ model in 2010. Scientists at the Institute have successfully produced a small silicon chip, no more than a few square inches, containing isolated living cells and tissues […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

2010 – European Union agrees on Directive 63/2010/EU

Europe-wide regulation of animals used for scientific purposes made a significant advancement with the adoption of Directive 63/2010/EU in September of 2010. The new directive improved on the previous one, Directive 86/609/EEC, by removing many of the discrepancies in protocols between European nations that often lead to quite obviously varying levels of protection for the […]

May 27th, 2014|Timeline, TL_legislation|Comments Off

2000- 3T3 Neutral Red Uptake (NRU) Phototoxicity Assay

In vitro phototoxicity tests measure skin irritation responses to agents without the need for an immune response.  This is accomplished by comparing the capacity for cell cultures to display a dye that is visible under UVA light in the presence or absence of the cytotoxic compound in question.  Such tests replace the need to test substances […]

June 26th, 2014|Timeline, TL_Alternatives|Comments Off

2000s – Significant advancements in real-time 3D imaging

Medical imaging took a noteworthy step forward with the introduction of the capacity for 3-dimensional imagery during the early 2000’s. Enhanced computer software and imaging devices, such as the CT, PET, and MRI scans have provided researchers the ability to view target areas with exceptional levels of detail further reducing the necessity for vivisection. 3D […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

2000s – Human Genome Project successfully maps human DNA

In June 2006 it was announced that the first working draft of the full human DNA sequence had been released by the Human Genome Project. In the years following researchers all over the world have used this resource to gain insight into a number of fields while reducing the need for animal testing. By studying […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

1996 – First successful cloning of a mammal – Dolly

In July 1996, the Roslin Institute of the University of Edinburgh accomplished one of the greatest and most controversial feats in modern science with the successful cloning of a mammalian adult cell. Dolly the sheep would be the first mammal born via the process of somatic cell transfer and would provide insight into the possibilities […]

May 27th, 2014|Timeline, TL_Alternatives|Comments Off

1993 – First World Congress

The first World Congress on Alternatives & Animal Use in the Life Sciences was held in Baltimore, Maryland, sponsored by CAAT (The Johns Hopkins University Center for Alternatives to Animal Testing) It remains the primary international scientific conference series dedicated to the 3Rs.

Further Congress meetings were held approximately every two years in  Utrecht, Netherlands;  Rome, Italy; Berlin, […]

June 19th, 2014|Timeline, TL_Social|Comments Off

1991 – LD50 test banned

The highly controversial Median Lethal Dose Test, or LD50, was developed by J. W. Trevan in 1927 as a means to determine characteristics in acute toxicity. However, due to the necessity to terminate large numbers of test subjects as a requisite of the test it received heavy criticism. In 1991 the UK Government decided upon […]

May 27th, 2014|Timeline, TL_legislation|Comments Off

1991 – Formation of ECVAM

In 1991 the European Union conceptualised the European Centre for the Validation of Alternative Methods (ECVAM) and, under the stewardship of Michael Balls, became an operational research unit in 1992. Based in Ispra, Italy ECVAM’s ‘main goal is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences […]

May 27th, 2014|Timeline, TL_Social|Comments Off