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Background Paper: cynomolgus monkeys and paracetamol

Cynomolgus monkeys are resistant to drug induced liver injury caused by paracetamol
by Dr Gerry Kenna
FRAME  Scientific Director

Prior to their registration for use in humans, all new drugs are subjected to a large battery of safety studies. These include an extensive series of investigations in experimental animals, which are undertaken in compliance with well-established regulatory guidelines, […]

October 30th, 2014|Press, Rightbox|Comments Off

FRAME Annual Lecture 2014

The latest FRAME Annual Lecture was a huge success and sparked an in-depth debate on the future of drug development and testing.

Speaker Dr Malcolm Skingle, Director of Academic Liaison at Glaxo Smith Kline, discussed using innovation to promote the Three Rs. He outlined changes in the use of animals to test new drugs and demonstrated […]

October 17th, 2014|Press, Rightbox|Comments Off

FRAME’s new Director

FRAME has appointed a new Director to oversee its research programme at the Nottingham office. Dr Gerry Kenna is a drug safety scientist with extensive industrial safety assessment experience, including 11 years in the pharmaceutical industry. Prior to that he had a highly successful academic career. He is recognised nationally and internationally in the field […]

October 6th, 2014|Press, Rightbox|Comments Off

Human Patient, Volunteer and Tissue Studies

As well as working with human cells, where possible the FRAME Alternatives Laboratory works with human patients and volunteers to increase understanding of human disease. Quite obviously, data obtained from human subjects is infinitely more relevant than data from animal models.
Dietary studies in overweight and obese humans
In conjunction with Clinicians and Physiologists at Nottingham University, we have […]

August 6th, 2014|Research, Rightbox|Comments Off

FRAME essay competition winner

FRAME’s recent essay competition “What are the alternatives to using animals in laboratories?” attracted some strong entries. The winner, who received a £300 prize, was 17-year-old Emma Bryan, a student at  Cheltenham Ladies College.

Emma’s response to her success: “I am extremely happy to have taken part as I really enjoyed writing the essay and am […]

July 21st, 2014|Rightbox|Comments Off

Development of a dynamic 3D model of liver for chronic toxicity testing

Technological advancements that provide the opportunity to develop better and more reliable models are essential to translational research.  At the FRAME Alternatives Laboratory at the University of Nottingham, PhD candidate Richard Maclennan has been working with the Zyoxel LiverChip device to determine its applicability and limitations for chronic toxicity testing.  The LiverChip recreates the in […]

July 1st, 2014|Research, Rightbox|Comments Off

Have your say

Seized illegal ivory could be used productively in medical experiments. But should it be? Take our one question survey and give us your opinion.

There has been an international ban on the trade in ivory since 1989, but hundreds of elephants are still killed by poachers. Last year saw record levels of ivory seizures around the world. […]

May 19th, 2014|Rightbox|Comments Off