FRAME receives no grants from central or local government and relies entirely on donations and legacies from individuals and companies who believe in what we do. We receive the majority of our funding from corporate supporters who make regular contributions to help our work. But we are also grateful to the many generous individuals who […]
The Home Office has issued a progress report on what it is doing to reduce the use of animals in scientific research. The department set out plans in a document last February, which included three strategic priorities.
advance the use of the ThreeRs within the UK;
use international leadership to influence the uptake and adoption of […]
The Home Office is to introduce a ban on testing household products on animals with effect from October. The move follows a detailed consultation about the impact such a ban would have on industry and the economy.
The ban will apply to products bought by the public for use at home and in the […]
Researchers have announced that it might be possible to transplant a human head onto a donor body within two years – but FRAME is concerned about the ethical and scientific questions surrounding the project.
FRAME Scientific Director Dr Gerry Kenna said: “At first glance, the proposal to transplant a human head to a different body has […]
Among the keynote speakers at the International Conference of Alternatives to Animal Experimentation in Portugal in May will be independent drug development consultant Dr Robert Coleman whose talk will be : Humanising drug safety testing: a pragmatic validation study.
Dr Coleman published a paper in the latest issue of FRAME’s scientific journal ATLA (Alternatives to Laboratory […]
FRAME is calling for increased investment in cell-based and computer methods of drug testing following new research that demonstrates serious flaws in an animal model.
Cynomolgus monkeys are considered a valuable species for drug testing because of their size and their relatively close genetic parallels with humans. Now new experiments to investigate how the liver handles […]
Cynomolgus monkeys are resistant to drug induced liver injury caused by paracetamol
by Dr Gerry Kenna
FRAME Scientific Director
Prior to their registration for use in humans, all new drugs are subjected to a large battery of safety studies. These include an extensive series of investigations in experimental animals, which are undertaken in compliance with well-established regulatory guidelines, […]
The latest FRAME Annual Lecture was a huge success and sparked an in-depth debate on the future of drug development and testing.
Speaker Dr Malcolm Skingle, Director of Academic Liaison at Glaxo Smith Kline, discussed using innovation to promote the Three Rs. He outlined changes in the use of animals to test new drugs and demonstrated […]
FRAME has appointed a new Director to oversee its research programme at the Nottingham office. Dr Gerry Kenna is a drug safety scientist with extensive industrial safety assessment experience, including 11 years in the pharmaceutical industry. Prior to that he had a highly successful academic career. He is recognised nationally and internationally in the field […]
As well as working with human cells, where possible the FRAME Alternatives Laboratory works with human patients and volunteers to increase understanding of human disease. Quite obviously, data obtained from human subjects is infinitely more relevant than data from animal models.
Dietary studies in overweight and obese humans
In conjunction with Clinicians and Physiologists at Nottingham University, we have […]