Details of research being carried out by FRAME at the lab, or desk-based.
The FRAME Alternatives Lab is able to differentiate human mononuclear blood cells into human osteoclasts (bone eating cells). Osteoclast dysfunction has been observed in a variety of bone diseases including osteoarthritis. The lab is currently investigating potential therapeutic agents which will decrease osteoclast activity in arthritis and reduce bone and joint damage.
Throughout its almost 50 year history FRAME’s researchers have authored very many scientific papers in both its own journal and others. They have also submitted articles to publications aimed at lay people, in order to promote the Three Rs to educators and the general public.
In addition they have written or translated a number of books […]
Much of the research into obesity and diabetes is carried out using transgenic animal models. FRAME’s experience and that of many others is that such animal models are of little use when trying to study human diseases and responses to potential therapies. The FRAME Alternatives Laboratory cultures primary human adipocytes and skeletal muscle myotubes to […]
It is well known that lipids (fatty substances) can have a positive effect on skin. A new project at the FRAME laboratory will enable close investigation of how lipids are absorbed to create those effects. The project will involve building three-dimensional models from keratinocytes, fibroblasts, melanocytes and immune cells. They will be isolated directly from […]
As well as working with human cells, where possible the FRAME Alternatives Laboratory works with human patients and volunteers to increase understanding of human disease. Quite obviously, data obtained from human subjects is infinitely more relevant than data from animal models.
Dietary studies in overweight and obese humans
In conjunction with Clinicians and Physiologists at Nottingham University, we have […]
Technological advancements that provide the opportunity to develop better and more reliable models are essential to translational research. At the FRAME Alternatives Laboratory at the University of Nottingham, PhD candidate Richard Maclennan has been working with the Zyoxel LiverChip device to determine its applicability and limitations for chronic toxicity testing. The LiverChip recreates the in […]
The use of genetically modified mice is increasing. This study is an investigation of the driving forces behind the rise in numbers of genetically modified (GM) mice in laboratories. Study of trends in the use of GM mice and their efficacy as a model for human disease. Inquiry into the scope of the areas of research, the […]
Cell based models to help identify potential new analgesics. Research focussing on elucidating the key molecular mechanisms by which fatty acid metabolites or lipids signal to ion channel proteins involved in pain detection in sensory neurons, that is, the chemical pathways by which the body feels pain. The overall aim of the project is to […]
Using donated human cells to investigate human reactions. The FRAME Alternatives Laboratory uses cells derived from human tissues to produce biologically relevant in vitro models of human organs, which behave and respond in the way they would in the body. Rather than growing cells as a single layer on plastic surfaces, it uses three dimensional scaffolds, […]
Non-human primates are used in many areas of medical research. An on-going study is being carried out to examine how research scientists view the opportunities and challenges of using primates in biomedical science, and to investigate the feasibility of phasing out their use. It focuses on investigations into two diseases, Schistosomiasis and Parkinson’s Disease.
The work is […]