Research

Details of research being carried out by FRAME at the lab, or desk-based.

Xenotransplantation survey

Between April 2014 and March 2015, 429 patients died waiting for an organ
transplant in the UK. A further 807 patients were removed from the transplant
list as deteriorating health meant that an organ donation would no longer be in the
patient’s best interest.

The lack of donated viable organs has led researchers to try to discover new methods […]

February 19th, 2016|Research|Comments Off

Transgenic mouse models for α-synuclein effects in Parkinson’s disease

FRAME carried out a review of mouse models used to study Parkinson’s disease. The findings were presented by intern Michelle Maurer from Johannes Gutenberg University of Mainz, Germany.

Download the slides by clicking here: Parkinsons_Mouse_Presentation

January 18th, 2016|Research|Comments Off

Using non‐animal methods to avoid human adverse drug reactions

FRAME Scientific Director Dr Gerry Kenna gave a lecture at the Dr Hadwen Trust Animal Replacement Science Conference.  His topic was Using non‐animal methods to predict and avoid human adverse drug reactions.

Download the slides by clicking here:  Adverse Drug Reactions.

December 14th, 2015|Press, Research|Comments Off

Human bone models in vitro

The FRAME Alternatives Lab is able to differentiate human mononuclear blood cells into human osteoclasts (bone eating cells). Osteoclast dysfunction has been observed in a variety of bone diseases including osteoarthritis. The lab is currently investigating potential therapeutic agents which will decrease osteoclast activity in arthritis and reduce bone and joint damage.

July 10th, 2015|Research|Comments Off

Publications database

Throughout its almost 50 year history FRAME’s researchers have authored very many scientific papers in both its own journal and others. They have also submitted articles to publications aimed at lay people, in order to promote the Three Rs to educators and the general public.

In addition they have written or translated a number of books […]

July 9th, 2015|Research|Comments Off

In vitro models of diabetes

Much of the research into obesity and diabetes is carried out using transgenic animal models. FRAME’s experience and that of many others is that such animal models are of little use when trying to study human diseases and responses to potential therapies. The FRAME Alternatives Laboratory cultures primary human adipocytes and skeletal muscle myotubes to […]

July 7th, 2015|Research|0 Comments

New skin model

It is well known that lipids (fatty substances) can have a positive effect on skin. A new project at the FRAME laboratory will enable close investigation of how lipids are absorbed to create those effects. The project will involve building three-dimensional models from keratinocytes, fibroblasts, melanocytes and immune cells. They will be isolated directly from […]

February 27th, 2015|Research|Comments Off

Human Patient, Volunteer and Tissue Studies

As well as working with human cells, where possible the FRAME Alternatives Laboratory works with human patients and volunteers to increase understanding of human disease. Quite obviously, data obtained from human subjects is infinitely more relevant than data from animal models.
Dietary studies in overweight and obese humans
In conjunction with Clinicians and Physiologists at Nottingham University, we have […]

August 6th, 2014|Research, Rightbox|Comments Off

Development of a dynamic 3D model of liver for chronic toxicity testing

Technological advancements that provide the opportunity to develop better and more reliable models are essential to translational research.  At the FRAME Alternatives Laboratory at the University of Nottingham, PhD candidate Richard Maclennan has been working with the Zyoxel LiverChip device to determine its applicability and limitations for chronic toxicity testing.  The LiverChip recreates the in […]

July 1st, 2014|Research, Rightbox|Comments Off

GM Mice

The use of genetically modified mice is increasing. This study is an investigation of the driving forces behind the rise in numbers of genetically modified (GM) mice in laboratories.  Study of trends in the use of GM mice and their efficacy as a model for human disease. Inquiry into the scope of the areas of research, the […]

June 26th, 2014|Research|Comments Off