FRAME is calling for increased investment in cell-based and computer methods of drug testing following new research that demonstrates serious flaws in an animal model.
Cynomolgus monkeys are considered a valuable species for drug testing because of their size and their relatively close genetic parallels with humans. Now new experiments to investigate how the liver handles […]
Cynomolgus monkeys are resistant to drug induced liver injury caused by paracetamol
by Dr Gerry Kenna
FRAME Scientific Director
Prior to their registration for use in humans, all new drugs are subjected to a large battery of safety studies. These include an extensive series of investigations in experimental animals, which are undertaken in compliance with well-established regulatory guidelines, […]
The latest FRAME Annual Lecture was a huge success and sparked an in-depth debate on the future of drug development and testing.
Speaker Dr Malcolm Skingle, Director of Academic Liaison at Glaxo Smith Kline, discussed using innovation to promote the Three Rs. He outlined changes in the use of animals to test new drugs and demonstrated […]
FRAME has appointed a new Director to oversee its research programme at the Nottingham office. Dr Gerry Kenna is a drug safety scientist with extensive industrial safety assessment experience, including 11 years in the pharmaceutical industry. Prior to that he had a highly successful academic career. He is recognised nationally and internationally in the field […]
The RSPCA has drawn up a plan that aims to end severe suffering for animals used in research and testing. The road-map has been released in response to changes in EU and UK legislation and has been published in FRAME’s scientific journal ATLA.
Until now scientists have not been required to record how many test animals […]
An abridged version of the book that first set out the Three Rs principles of alternatives to animal experimentation has been translated into Chinese, and will be distributed to libraries and universities throughout China.
China has so far been slow to adopt alternatives – cosmetics testing on animals is still required by law there, for example […]
FRAME is calling for more collaboration between alternatives organisations, government and the pharmaceutical industry following publication of a new investigation of preclinical drugs trials using laboratory animals.
Scientific papers covering more than 2,300 substances tested on rats, mice and rabbits were analysed to measure the likelihood ratio that chemicals showing no adverse reactions would behave the same […]
A further increase in the use of genetically altered (GA) animals in laboratories flouts EU regulations and is in direct opposition to the UK Government’s pledge to reduce the numbers involved. If the Government is going to keep its promise it needs to address this question urgently in order to stop the upward trend.
FRAME is deeply […]
As part of an ongoing programme of modernisation FRAME has overhauled its website and updated the content. The process began two years ago with the launch of PiLAS (Perspectives in Laboratory Animal Science), which was given its own online presence as well as being published in print as part of FRAME’s peer-reviewed journal ATLA (Alternatives […]