FRAME is calling for increased investment in cell-based and computer methods of drug testing following new research that demonstrates serious flaws in an animal model.
Cynomolgus monkeys are considered a valuable species for drug testing because of their size and their relatively close genetic parallels with humans. Now new experiments to investigate how the liver handles […]
The latest FRAME Annual Lecture was a huge success and sparked an in-depth debate on the future of drug development and testing.
Speaker Dr Malcolm Skingle, Director of Academic Liaison at Glaxo Smith Kline, discussed using innovation to promote the Three Rs. He outlined changes in the use of animals to test new drugs and demonstrated […]
The RSPCA has drawn up a plan that aims to end severe suffering for animals used in research and testing. The road-map has been released in response to changes in EU and UK legislation and has been published in FRAME’s scientific journal ATLA.
Until now scientists have not been required to record how many test animals […]
An abridged version of the book that first set out the Three Rs principles of alternatives to animal experimentation has been translated into Chinese, and will be distributed to libraries and universities throughout China.
China has so far been slow to adopt alternatives – cosmetics testing on animals is still required by law there, for example […]
FRAME staff and Trustees, and post-graduates from the FRAME Alternatives Laboratory took part in the ninth World Congress on Alternatives and Animal Use in the Life Sciences, in Prague, Czech Republic.
Two posters featuring FRAME research were displayed. One was by FRAME Scientific Officer Kevin Coll, on the rise in use of genetically modified (GM) mice […]
FRAME is calling for more collaboration between alternatives organisations, government and the pharmaceutical industry following publication of a new investigation of preclinical drugs trials using laboratory animals.
Scientific papers covering more than 2,300 substances tested on rats, mice and rabbits were analysed to measure the likelihood ratio that chemicals showing no adverse reactions would behave the same […]
A further increase in the use of genetically altered (GA) animals in laboratories flouts EU regulations and is in direct opposition to the UK Government’s pledge to reduce the numbers involved. If the Government is going to keep its promise it needs to address this question urgently in order to stop the upward trend.
FRAME is deeply […]
The use of animals in experiments is well documented. Its history and evolution can be traced through to contemporary techniques. Centuries ago, the ancient Greeks and Romans first began exploratory surgery on animals to discover the inner workings of living things. However, until now there has never been a simple way to track the developments […]
There has been an overall decrease in the total number of animals used for scientific procedures in the past 40 years. However, there has been a consistent increase in the breeding and use of genetically modified animals, mostly mice, over the same period.
Genetically modified mice (GMM) have become a routine model for researchers in a […]