Background

/Background

Why human in vitro models are needed

Cross-species extrapolation is needed to assess the human relevance of effects observed in animals. In vitro to in vivo extrapolation is needed to assess the in vivo relevance of effects observed in in vitro assays. Both extrapolations have their own limitations. In vivo animal studies are ethically undesirable, while oversimplified in vitro assays will not [...]

October 20th, 2015|Background|Comments Off on Why human in vitro models are needed

Statistics of Scientific Procedures on Living Animals in Great Britain

Scientists in the UK who work with animals are required by law to submit reports to the Home Office about their use, and the figures are collated and released annually by the department. The statistics are used to inform government policies on animal use in scientific work and to provide information for the scientific community, [...]

October 15th, 2015|Background|Comments Off on Statistics of Scientific Procedures on Living Animals in Great Britain

Supplementary data for Chen et al. paper in ATLA 43, issue 4

The attached data is designed to be used in conjunction with a paper in ATLA, FRAME's peer-reviewed journal. It is associated with  Summary and Analysis of the Currently Existing Literature Data on Metal-based Nanoparticles Published for Selected Aquatic Organisms: Applicability for Toxicity Prediction by (Q)SARs  by Guangchao Chen, Martina G. Vijver and Willie J.G.M. Peijnenburg. Abstract This review [...]

October 1st, 2015|Background|Comments Off on Supplementary data for Chen et al. paper in ATLA 43, issue 4

Cynomolgus monkeys and paracetamol: background paper

Cynomolgus monkeys are resistant to drug induced liver injury caused by paracetamol by Dr Gerry Kenna Prior to their registration for use in humans, all new drugs are subjected to a large battery of safety studies. These include an extensive series of investigations in experimental animals, which are undertaken in compliance with well-established regulatory guidelines, [...]

October 30th, 2014|Background, Press, Rightbox|Comments Off on Cynomolgus monkeys and paracetamol: background paper