News & Views  [ Abstract ]   [ PDF ]

Maggy Jennings
Editorial: Refinement: A Sense of Progress    [ PDF ]

IIVS News & Views  [ Abstract ]   [ PDF ]

Michael Balls
Preface: Special Anniversary Volume - Issue 2: Refinement    [ PDF ]

Maggie Lloyd
Advancing Refinement Through Training: Is There a Role for Reflective Practice?  [ Abstract ]   [ PDF ]

Jon O. Curwen and Stephen R. Wedge
The Use and Refinement of Rodent Models in Anti-cancer Drug Discovery: A Review  [ Abstract ]   [ PDF ]

Margaret Rose
Welfare Phenotyping of Genetically-modified Mice  [ Abstract ]   [ PDF ]

Marilyn J. Brown and William J. White
Reflections on Improved Health Status of Rodents Bred for Research: Contributions to the Reduction and Refinement of Animal Use  [ Abstract ]   [ PDF ]

Dinesh K. Badyal, Vikas Modgill and Jasleen Kaur
Computer Simulation Models are Implementable as Replacements for Animal Experiments  [ Abstract ]   [ PDF ]

Shoko Obora and Tsutomu Kurosawa
Implementation of the Three Rs in Biomedical Research — Has the Turn of the Century Turned the Tide?  [ Abstract ]   [ PDF ]

Mathieu Vinken, Elke Decrock, Elke De Vuyst, Luc Leybaert, Tamara Vanhaecke and Vera Rogiers
Biochemical Characterisation of an In Vitro Model of Hepatocellular Apoptotic Cell Death  [ Abstract ]   [ PDF ]

Nigel Moore, Susanne Bremer, Neil Carmichael, George Daston, Matt Dent, Wassila Gaoua-Chapelle, Nina Hallmark, Thomas Hartung, Beate Holzum, Ulrich Hübel, Marie-Louise Meisters, Steffen Schneider, Bennard van Ravenzwaay and Christa Hennes
A Modular Approach to the Extended One-generation Reproduction Toxicity Study - The Outcome of an ECETOC Task Force and International ECETOC/ECVAM Workshop  [ Abstract ]   [ PDF ]