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Supplement 1A


The Three Rs at the Beginning of
the 21st Century.
Proceedings of the Fourth World Congress on Alternatives and Animal Use in the Life Sciences


ATLA Volume 32, S1A

June 2004


Andrew N. Rowan
Fourth World Congress - Preface  [ Abstract ]   [ PDF ]

Fourth World Congress - Contents    [ PDF ]

W.M.S. Russell
Fourth World Congress - Special contribution: Nine Glorious Years    [ PDF ]

Paul De Greeve, Wim De Leeuw and Bert F.M. van Zutphen
Plenary lecture: Trends in Animal Use and Animal Alternatives  [ Abstract ]   [ PDF ]

Jean S. Fleming
Plenary lecture - Ethical, Cultural and Spiritual Objections to Genetically Modified Organisms: A Review of the New Zealand Process and Perspective  [ Abstract ]   [ PDF ]

Adrian J. Smith and Karina Smith
Plenary lecture - Guidelines for Humane Education: Alternatives to the Use of Animals in Teaching and Training  [ Abstract ]   [ PDF ]

Robert D. Combes
The Use of Human Cells in Biomedical Research and Testing  [ Abstract ]   [ PDF ]

Samantha Orr and Jacki Trafford
The Establishment of the UK Human Tissue Bank  [ Abstract ]   [ PDF ]

Peggy Papeleu, Pascal Loyer, Tamara Vanhaecke, Tom Henkens, Greetje Elaut, Christiane Guguen-Guillouzo and Vera Rogiers
Proliferation of Epidermal Growth Factor-stimulated Hepatocytes in a Hormonally Defined Serum-free Medium  [ Abstract ]   [ PDF ]

Celia P. Martínez-Jiménez, Ramiro Jover, Maria José Gómez-Lechón and José V. Castell
Can Hepatoma Cell Lines be Redifferentiated to be Used in Drug Metabolism Studies?  [ Abstract ]   [ PDF ]

Joseph Kubilus, Patrick J. Hayden, Seyoum Ayehunie, Sarah D.K. Lamore, Cynthia Servattalab, Kristen L. Bellavance, John E. Sheasgreen and Mitchell Klausner
Full Thickness EpiDerm™: a Dermal–Epidermal Skin Model to Study Epithelial–Mesenchymal Interactions  [ Abstract ]   [ PDF ]

Roland Roguet
The Use of Reconstructed Human Epidermis EPISKIN™ in the Assessment of Local Tolerance of Cosmetics and Chemicals  [ Abstract ]   [ PDF ]

Marlies Halder, Michael Balls, Coenraad Hendriksen and Klaus Cussler
ECVAM’s Activities in Promoting the Three Rs in the Quality Control of Biologicals  [ Abstract ]   [ PDF ]

Yasuyuki Sakai, Osamu Fukuda, Sue-Hyung Choi and Akiyoshi Sakoda
Use of a Perfusion Co-culture System Consisting of Caco-2 and Hep G2 Cell Compartments for the Kinetic Analysis of Benzo[a]pyrene Toxicity  [ Abstract ]   [ PDF ]

Greetje Elaut, Gabriëlla Török, Peggy Papeleu, Tamara Vanhaecke, Georges Laus, Dirk Tourwé and Vera Rogiers
Rat Hepatocyte Suspensions as a Suitable In Vitro Model for Studying the Biotransformation of Histone Deacetylase Inhibitors  [ Abstract ]   [ PDF ]

Nicolas Fabre, Elsa Arrivet, Françoise Paillard, Valérie Wibaut-Berlaimont, Nicole Bichet, Nigel O. Roome, Annick Prenez and Joan-Albert Vericat
A New Human Hepatoma Cell Line to Study Repeated Cell Toxicity  [ Abstract ]   [ PDF ]

Vera Baumans
Report of the Workshop on Fetal Bovine Serum Replacement in Cell Cultures    [ PDF ]

John McArdle
Report of the Workshop on Monoclonal Antibodies    [ PDF ]

André Schratten
Potential of Comprehensive Toxico-proteomics: Quantitative and Differential Mining of Functional Proteomes from Native Samples  [ Abstract ]   [ PDF ]

Michael F.W. Festing
Good Experimental Design and Statistics Can Save Animals, But How Can it Be Promoted?  [ Abstract ]   [ PDF ]

Rajendra S. Chhabra, Nancy B. Ress, John W. Harbell and Rodger D. Curren
Evaluation of Some In Vitro Tests to Reduce and Replace the Sub-acute Animal Toxicity Studies  [ Abstract ]   [ PDF ]

David J. Mellor
Taming and Training of Pregnant Sheep and Goats and of Newborn Lambs, Kids and Calves before Experimentation  [ Abstract ]   [ PDF ]

David J. Mellor and Vera Baumans
Introduction: Evaluation Techniques for Animal Well-being    [ PDF ]

Sarah Wolfensohn
Social Housing of Large Primates: Methodology for Refinement of Husbandry and Management  [ Abstract ]   [ PDF ]

Georgia Mason, David Wilson, Charlotte Hampton and Hanno Würbel
Non-invasively Assessing Disturbance and Stress in Laboratory Rats by Scoring Chromodacryorrhoea  [ Abstract ]   [ PDF ]

Vera Baumans
Methods for Evaluation of Laboratory Animal Well-being  [ Abstract ]   [ PDF ]

Eva Waiblinger and Barbara König
Refinement of Gerbil Housing and Husbandry in the Laboratory  [ Abstract ]   [ PDF ]

Rosemarie Einstein, Robyn L. Billing, Anureet Singh and Irene Chin
Implanted Telemetry Transmitters Alter the Noradrenergic Response in Vas Deferens from Mice  [ Abstract ]   [ PDF ]

Klaas Kramer, Heleen van de Weerd, Anne Mulder, Caroline Van Heijningen, Vera Baumans, René Remie, Hans-Peter Voss and Bert F.M. van Zutphen
Effect of Conditioning on the Increase of Heart Rate and Body Temperature Provoked by Handling in the Mouse  [ Abstract ]   [ PDF ]

David Anderson
Revision of Council of Europe Convention ETS 123 Guidelines for the Accommodation and Care of Animals Used for Experimental and Other Scientific Purposes  [ Abstract ]   [ PDF ]

Ursula G. Sauer
The Revision of European Housing Guidelines for Laboratory Animals: Expectations from the Point of View of Animal Welfare  [ Abstract ]   [ PDF ]

Kay L. Stewart
The Environmental Enrichment Committee  [ Abstract ]   [ PDF ]

Ajit Kale1 Ivo Amende, Katrina Piskorski, Victor Chu, Jose M. Otero, Peter Mueller and Thomas G. Hampton
Non-invasive Physiology in Conscious Mice  [ Abstract ]   [ PDF ]

Christian Cook and David Thomas
Reducing the Invasiveness of Obtaining Blood-borne Measures in Animals  [ Abstract ]   [ PDF ]

James K. Kirkwood
Use and Pitfalls of Allometry: A Valuable Tool in Comparisons and Extrapolations Between Species and in Ethical Considerations Concerning the Use of One Species to Model Another  [ Abstract ]   [ PDF ]

Gilly Griffin and Clément Gauthier
Incorporation of the Principles of the Three Rs in Wildlife Research  [ Abstract ]   [ PDF ]

Jane Conole
The Ethics of Research on Companion Animals for the Benefit of Their Own Species  [ Abstract ]   [ PDF ]

Michael D. Rickard
The Use of Animals for Research on Animal Diseases: Its Impact on the Harm–Benefit Analysis  [ Abstract ]   [ PDF ]

Bruce Warburton and Cheryl O’Connor
Research on Vertebrate Pesticides and Traps: Do Wild Animals Benefit?  [ Abstract ]   [ PDF ]

Ian G. Colditz
Welfare Benefits to Farm Animals from Their Use in Research  [ Abstract ]   [ PDF ]

Derek Fry
Reduction by Well-defined Objectives  [ Abstract ]   [ PDF ]

Sylvia Vaughan
Optimising Resources by Reduction: The FRAME Reduction Committee  [ Abstract ]   [ PDF ]

Maria Puopolo, Aldina Venerosi Pesciolini, Flavia Chiarotti and Laura Ricceri
Adequate Statistical Methods to Reduce the Number of Animals Used in Behavioural Experiments: The Analysis of the Behavioural Transitions  [ Abstract ]   [ PDF ]

Michael F.W. Festing
Refinement and Reduction Through the Control of Variation  [ Abstract ]   [ PDF ]

Paul Flecknell and Alicia Karas
Assessing and Managing Pain and Distress for Ethics Committees    [ PDF ]

David J. Mellor and Kevin J. Stafford
Physiological and Behavioural Assessment of Pain in Ruminants: Principles and Caveats  [ Abstract ]   [ PDF ]

Clément Gauthier
Overview and Analysis of Animal Use in North America  [ Abstract ]   [ PDF ]

A.C. David Bayvel
Animal Use Statistics: The New Zealand and Australian Experience and Perspective  [ Abstract ]   [ PDF ]

Jon D. Richmond
Animal Use in the United Kingdom in 2001  [ Abstract ]   [ PDF ]

Yukihisa Matsuda
Recent Trends in the Number of Laboratory Animals Used in Japan  [ Abstract ]   [ PDF ]

Annamaria Passantino, Marzio Panichi, Maria Rachele Russo and Michele Passantino
Ethics for Research Using Animals in Italy  [ Abstract ]   [ PDF ]

David B. Morton
The Welfare of Non-human Primates in Research in the EU  [ Abstract ]   [ PDF ]

Ursula G. Sauer
The Moral Standing of Non-human Primates: Why They Merit Special Consideration  [ Abstract ]   [ PDF ]

Kathleen M. Conlee, Erika H. Hoffeld and Martin L. Stephens
A Demographic Analysis of Primate Research in the United States  [ Abstract ]   [ PDF ]

Mark J. Prescott and Maggy Jennings
Ethical and Welfare Implications of the Acquisition and Transport of Non-human Primates for Use in Research and Testing  [ Abstract ]   [ PDF ]

Neil Wells
The Great Ape Project: Legislating for the Control of the Use of Non-human Hominids in Research, Testing and Teaching — Animal Welfare Act 1999 (New Zealand)  [ Abstract ]   [ PDF ]

Andrew Nicholson, Jessica Sandler and Troy Seidle
An Evaluation of the US High Production Volume (HPV) Chemical-testing Programme: A Study in (Ir)Relevance, Redundancy and Retro Thinking  [ Abstract ]   [ PDF ]

Ursula G. Sauer
The New EU Chemicals Policy: Challenges and Chances for Animal-free Test Methods  [ Abstract ]   [ PDF ]

Vera Rogiers
ECOPA: The European Consensus Platform on Three Rs Alternatives  [ Abstract ]   [ PDF ]

Jon D. Richmond
Humane Regulatory Testing: The United Kingdom Experience  [ Abstract ]   [ PDF ]

Sidney Green and Alan M. Goldberg
TestSmart and Toxic Ignorance  [ Abstract ]   [ PDF ]

Irmela W. Ruhdel
EU Sales Ban on New Cosmetics Tested on Animals: Impact on Alternative Methods, WTO Implications and Animal Welfare Aspects  [ Abstract ]   [ PDF ]

Vicky Robinson and Maggy Jennings
Refinement and Reduction in the Production of Genetically Modified Mice: Sixth Report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement  [ Abstract ]   [ PDF ]

A.C. David Bayvel
Animal Use in Biotechnology: Issues and Options — A New Zealand Perspective  [ Abstract ]   [ PDF ]

Lino Enrique Paula
Effective Policies in the Animal Genomics Era: How Best to Involve Ethics, Expertise and the Public  [ Abstract ]   [ PDF ]

Miranda Gott and Vaughan Monamy
Ethics and Transgenesis: Toward a Policy Framework Incorporating Intrinsic Objections and Societal Perceptions  [ Abstract ]   [ PDF ]