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Alternatives to Laboratory Animals - ATLA

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Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects

ATLA Volume 33, S1

July 2005

 


Foreword, Preface and Overview  [ Abstract ]   [ PDF ]


Executive Summary  [ Abstract ]   [ PDF ]

Martine Ruet Rossignol
Chapter 1: The 7th Amendment to the Cosmetics Directive    [ PDF ]

Irene Manou, Chantra Eskes, Odile de Silva, Gerald Renner, and Valérie Zuang
Chapter 2: Safety Data Requirements for the Purposes of the Cosmetics Directive; From Animal Testing to Alternative Methods; Considerations with Regard to the Estimated Timings    [ PDF ]

Laura Gribaldo, Alessandra Gennari, Karen Blackburn, Cecilia Clemedson, Alain Deguercy, Annarita Meneguz, Walter Pfaller and Irmela Ruhdel
Chapter 3.1: Acute Toxicity    [ PDF ]

Valérie Zuang, Marie-Ange Alonso, Philip A. Botham, Chantra Eskes, Julia Fentem, Manfred Liebsch and Johannes J.M. van de Sandt
Chapter 3.2: Skin Irritation and Corrosion    [ PDF ]

Chantra Eskes, Sandrine Bessou, Leon Bruner, Rodger Curren, John Harbell, Penny Jones, Reinhard Kreiling, Manfred Liebsch, Pauline McNamee, Wolfang Pape, Menk K. Prinsen, Troy Seidle, Philippe Vanparys, Andrew Worth and Valérie Zuang
Chapter 3.3: Eye Irritation    [ PDF ]

David Basketter, Silvia Casati, G. Frank Gerberick, Peter Griem, Barry Philips and Andrew Worth
Chapter 3.4: Skin Sensitisation    [ PDF ]

Walter Diembeck, Chantra Eskes, Jon R. Heylings, Gill Langley, Vera Rogiers, Johannes J.M. van de Sandt and Valérie Zuang
Chapter 3.5: Skin Absorption and Penetration    [ PDF ]

Pilar Prieto, Cecilia Clemedson, Annarita Meneguz, Walter Pfaller, Ursula G. Sauer and Carl Westmoreland
Chapter 3.6: Subacute and Subchronic Toxicity    [ PDF ]

Daniela Maurici, Marilyn Aardema, Raffaella Corvi, Marcus Kleber, Cyrille Krul, Christian Laurent, Nicola Loprieno, Markku Pasanen, Stefan Pfuhler, Barry Phillips, Enrico Sabbioni, Tore Sanner and Philippe Vanparys
Chapter 3.7: Genotoxicity and Mutagenicity    [ PDF ]

Manfred Liebsch, Horst Spielmann, Wolfgang Pape, Cyrille Krul, Alain Deguercy and Chantra Eskes
Chapter 3.8: UV-induced Effects    [ PDF ]

Sandra Coecke, Bas J. Blaauboer, Greetje Elaut, Stuart Freeman, Andreas Freidig, Nigel Gensmantel, Peter Hoet, Vassilios M. Kapoulas, Bernhard Ladstetter, Gill Langley, David Leahy, Geert Mannens, Annarita Meneguz, Mario Monshouwer, Ben Nemery, Olavi Pelkonen, Walter Pfaller, Pilar Prieto, Nick Proctor, Vera Rogiers, Amin Rostami-Hodjegan, Enrico Sabbioni, Winfried Steiling and Johannes J.M. van de Sandt
Chapter 3.9: Toxicokinetics and Metabolism    [ PDF ]

Daniela Maurici, Marilyn Aardema, Raffaella Corvi, Marcus Kleber, Cyrille Krul, Christian Laurent, Nicola Loprieno, Markku Pasanen, Stefan Pfuhler, Barry Phillips, David Prentice, Enrico Sabbioni, Tore Sanner and Philippe Vanparys
Chapter 3.10: Carcinogenicity    [ PDF ]

Susanne Bremer, Rita Cortvrindt, George Daston, Brighitta Eletti, Alberto Mantovani, Francesca Maranghi, Olavi Pelkonen, Irmela Ruhdel and Horst Spielmann
Chapter 3.11: Reproductive and Developmental Toxicity    [ PDF ]


Appendix 1: Particpating Stakeholders and Commission Services    [ PDF ]


Appendix 2: Participating scientific experts nominated by commission services and stakeholders    [ PDF ]


APPENDIX 3: Glossary of Terms    [ PDF ]

Juan M. Riego Sintes
APPENDIX 4: Methods Adopted by the EU for Testing Chemicals    [ PDF ]

Patric Amcoff
Appendix 5: OECD Guidelines for the Testing of Chemicals    [ PDF ]