Robert Combes and Michael Balls
Editorial: Opportunities for the Government to Actively Promote the Three Rs during the UK’s Presidency of the European Union (1 July to 31 December 2005)  [ Abstract ]   [ PDF ]

News & Views  [ Abstract ]   [ PDF ]

ECVAM News & Views  [ Abstract ]   [ PDF ]

José Cotovio, Marie-Hélène Grandidier, Pascal Portes, Roland Roguet and Gilles Rubinstenn
The In Vitro Acute Skin Irritation of Chemicals: Optimisation of the EPISKIN Prediction Model within the Framework of the ECVAM Validation Process  [ Abstract ]   [ PDF ]

Helena Kandárová, Manfred Liebsch, Ingrid Gerner, Elisabeth Schmidt, Elke Genschow, Dieter Traue and Horst Spielmann
The EpiDerm Test Protocol for the Upcoming ECVAM Validation Study on In Vitro Skin Irritation Tests — An Assessment of the Performance of the Optimised Test  [ Abstract ]   [ PDF ]

Jasmijn de Boo and Coenraad Hendriksen
Reduction Strategies in Animal Research: A Review of Scientific Approaches at the Intra-experimental, Supra-experimental and Extra-experimental Levels  [ Abstract ]   [ PDF ]

Raffaella Melani, Renata Rebaudo, Jens Noraberg, Jens Zimmer and Maurizio Balestrino
Changes in Extracellular Action Potential Detect Kainic Acid and Trimethyltin Toxicity in Hippocampal Slice Preparations Earlier than do MAP2 Density Measurements  [ Abstract ]   [ PDF ]

Tukaram More, Golla Ramalinga Reddy and Sandeep Kumar
An Evaluation of the Metabolic Basis of Aflatoxin B1 Toxicity by Using Buffalo Granulocytes and Agranulocytes In Vitro  [ Abstract ]   [ PDF ]

Susanne Bremer, Donatella Balduzzi, Rita Cortvrindt, George Daston, Brighitta Eletti, Andrea Galli, Ilpo Huhtaniemi, Susan Laws, Giovanna Lazzari, Ulla Liminga, Johan Smitz, Marcello Spano, Axel Themmen, Anne Tilloy and Ine Waalkens-Behrends
The Effects of Chemicals on Mammalian Fertility The Report and Recommendations of ECVAM Workshop 53 — the First Strategic Workshop of the EU ReProTect Project  [ Abstract ]   [ PDF ]

Christina Grindon and Nirmala Bhogal
Comment: The Fourth EC Report on the Statistics of Laboratory Animal Use: Trends, Recommendations and Future Prospects  [ Abstract ]   [ PDF ]