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ATLA - ISI
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Alternatives to Laboratory Animals - ATLA

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ATLA Volume 37, No 5

November 2009

 

Mark T.D. Cronin
Editorial: In Silico Toxicology Challenges for Pharmaceuticals:Complacency or Controversy?    [ PDF ]


News & Views  [ Abstract ]   [ PDF ]


ECVAM News & Views  [ Abstract ]   [ PDF ]

Michael Balls
Preface - Special Anniversary Volume - Issue 5: Replacement - Focus on In Silico Methods    [ PDF ]

Scott Boyer
The Use of Computer Models in Pharmaceutical Safety Evaluation  [ Abstract ]   [ PDF ]

Simon Thomas
Physiologically-based Simulation Modelling for the Reduction of Animal Use in the Discovery of Novel Pharmaceuticals  [ Abstract ]   [ PDF ]

Mark T.D. Cronin, Fania Bajot, Steven J. Enoch, Judith C. Madden, David W. Roberts and Johannes Schwöbel
The In Chemico–In Silico Interface: Challenges for Integrating Experimental and Computational Chemistry to Identify Toxicity  [ Abstract ]   [ PDF ]


Computational Toxicology Approaches at the US Food and Drug Administration  [ Abstract ]   [ PDF ]

Claire M. Ellison, Steven J. Enoch, Mark T.D. Cronin, Judith C. Madden and Philip Judson
Definition of the Applicability Domains of Knowledgebased Predictive Toxicology Expert Systems by Using a Structural Fragment-based Approach  [ Abstract ]   [ PDF ]

Zvezdana Z. Kojic and David G. Dewhurst
The Impact of Introducing Computer-based Alternatives to the Use of Animals in the Teaching of Physiology and Pharmacology at Balkan Universities — A Pilot Study  [ Abstract ]   [ PDF ]

J. Arie Vonk, Romualdo Benigni, Mark Hewitt, Monika Nendza, Helmut Segner, Dik van de Meent and Mark T.D. Cronin
The Use of Mechanisms and Modes of Toxic Action in Integrated Testing Strategies: The Report and Recommendations of a Workshop held as part of the European Union OSIRIS Integrated Project  [ Abstract ]   [ PDF ]

Nirmala Bhogal
Conference Report: Improving the Availability of Human Tissues for Medical Research in the UK  [ Abstract ]   [ PDF ]

Angelo Vedani and Martin Smiesko
In Silico Toxicology in Drug Discovery — Concepts Based on Three-dimensional Models  [ Abstract ]   [ PDF ]