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Comment: The OECD Health Effects Test Guidelines: A Challenge to the Sincerity of Commitment to the Three Rs

Michael Balls and Robert D. Combes

This introductory comment is followed by three written comments which we have received for publication: from Angela Auletta, an experienced regulator, formerly at the US Environmental Protection Agency (EPA), who also served on secondment to the OECD TG Programme, John Doe, Richard Lewis and Philip Botham, toxicologists at the Syngenta Central Toxicology Laboratory,and Barry Phillips, an experienced toxicologist, now at the RSPCA.