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Cytotoxic and Genotoxic Effects of Sodium Fluoride on Mammalian Cells at Neutral or Acid pH: a Summary of Published Work


Darina Slameñová, Alena Gábelová, Katarina Ruppová and Ladislave Wsólová

This paper forms a short review of some of our previously published work. We assessed the cytotoxic and genotoxic effects of sodium fluoride (NaF) on the Chinese hamster V79 cell line and the human EUE cell line at neutral and acid pH (as found in the stomach). The effects of NaF on cell proliferation, DNA synthesis, protein synthesis and mutagenesis were assessed. The results found showed no mutagenic effects after exposure to NaF, despite some cytogenic effects, suggesting that NaF probably does not represent any serious mutagenic or carcinogenic threat to humans.