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The Production of Polyclonal Antibodies in Laboratory Animals The Report and Recommendations of ECVAM Workshop 35

P.P.A. Marlies Leenaars, Coenraad F.M. Hendriksen, Wim A. de Leeuw, Florina Carat, Philippe Delahaut, René Fischer, Marlies Halder, W. Carey Hanly, Joachim Hartinger, Jann Hau, Erik B. Lindblad, Werner Nicklas, Ingrid M. Outschoorn and Duncan E.S. Stewart-Tull

This is the report of the thirty-fifth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM).  This joint ECVAM/FELASA (Federation of European Laboratory Animal Science Associations) workshop on The Immunisation of Laboratory Animals for the Production of Polyclonal Antibodies was held in Utrecht (The Netherlands), on 20–22 March 1998, under the co-chairmanship of Coenraad Hendriksen (RIVM, Bilthoven, The Netherlands) and Wim de Leeuw (Inspectorate for Health Protection, The Netherlands). The participants, all experts in the fields of immunology, laboratory animal science, or regulation, came from universities, industry and regulatory bodies. The aims of the workshop were: a) to discuss and evaluate current immunisation procedures for the production of polyclonal antibodies (including route of injection, animal species and adjuvant); and b) to draft recommendations and guidelines to improve the immunisation procedures, with regard both to animal welfare and to the optimisation of immunisation protocols. This report summarises the outcome of the discussions and includes a number of recommendations and a set of draft guidelines (included in Appendix 1).