Pharmacokinetics in Early Drug Research The Report and Recommendations of ECVAM Workshop 22

David E. Leahy, Ruth Duncan, Hans J. Ahr, Martin K. Bayliss, A. (Bert) G. de Boer, Ferenc Darvas, Julia H. Fentem, Jeffrey R. Fry, Robert Hopkins, J. Brian Houston, Johan Karlsson, Gregory L. Kedderis, Margaret K. Pratten, Pilar Prieto, Dennis A. Smith and Donald W. Straughan

This is the report of the twenty-second of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The workshop on Pharmacokinetics in Early Drug Research was held in Bath, UK, on 27–29 March 1996, under the co-chairmanship of David Leahy (ZENECA Pharmaceuticals, Macclesfield, UK) and Ruth Duncan (School of Pharmacy, London, UK). The aims of the workshop were to: a) review the current methodology for providing early pharmacokinetic and related information; b) define current best practice and identify those problem areas where scientific and technological advances could significantly improve the efficiency of drug discovery; and c) recommend further work which should be conducted in these high priority areas.