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Alternatives to Laboratory Animals - ATLA

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ECVAM's Activities on Computer Modelling and Integrated Testing

Andrew P. Worth

This paper introduces the basic concepts of quantitative structure.activity relationship (QSAR), expert system and integrated testing strategy, and explains how the analogy between QSARs and prediction models leads naturally to criteria for the validation of QSARs. ECVAM.s in-house research programme on QSAR modelling and integrated testing is summarised, along with plans for the validation of QSAR models and expert system rulebases at the European Union level.