Home banner
A-Z Index

Quick way to the find the information that you need...

More button
Register with FRAME

Although you do not need to register, any information you provide will be confidential and used only by FRAME to improve the website

Register button
Account Login
Forgot password?

The Journal


Alternatives to Laboratory Animals - ATLA

Download latest issue button Download back issues button Subscribe to ATLA
Contact Us

Tel icon

Tel: +44 (0)115 9584740

Tel icon

Fax: +44 (0)115 9503570

Make an Enquiry

Selected Biostatistical Aspects of the Validation of In Vitro Toxicological Assays

Ludwig A. Hothorn

An overview is presented on selected biostatistical spects of the validation of in vitro toxicological assays. Primarily, the statistical analysis of single assays is discussed. Several approaches are compared for the possible non-monotonic dose–response relationship with a priori unknown shapes. The use of confidence intervals instead of p values for toxicologically appropriate decision making is explained. New methods for demonstrating interlaboratory similarity for dose–response designs are discussed. For validation, the inappropriateness of the concordance coefficient is shown, and sensitivity and specificity, as well as predictive values, are proposed as alternatives. The problem of the missing gold standard is highlighted.