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The Practical Application of Three Validated In Vitro Embryotoxicity Tests The Report and Recommendations of an ECVAM/ZEBET Workshop (ECVAM Workshop 57)

Horst Spielmann, Andrea Seiler, Susanne Bremer, Lars Hareng, Thomas Hartung, Hans Ahr, Elaine Faustman, Ulla Haas, Graeme J. Moffat, Heinz Nau, Philippe Vanparys, Aldert Piersma, Juan Riego Sintes and Jane Stuart

In line with the recommendations of an ECVAM workshop on reproductive toxicity, held in 1994, ECVAM initiated and funded a validation study of three in vitro embryotoxicity tests. In two of these assays, pregnant laboratory animals are used to obtain embryonic tissue — either primary embryonic cells in the mouse micromass (MM) test or embryos in the rat whole embryo culture (WEC) test. In contrast, in the embryonic stem cell test (EST) a permanent mouse embryonic stem cell line is used.