Home banner
Divider
A-Z Index

Quick way to the find the information that you need...

More button
Register with FRAME

Although you do not need to register, any information you provide will be confidential and used only by FRAME to improve the website

Register button
Account Login
Forgot password?

ATLA - ISI
The Journal

 

Alternatives to Laboratory Animals - ATLA

Download latest issue button Download back issues button Subscribe to ATLA
Contact Us

Tel icon

Tel: +44 (0)115 9584740


Tel icon

Fax: +44 (0)115 9503570

Make an Enquiry

Structural Basis of the Toxicity of Chemicals in Cultured Human HeLa Cells


Xinyu Zhu and Herbert S. Rosenkranz

A coherent structure-activity relationship (SAR) model was derived from data based on the toxicity of chemicals in cultured human HeLa cells. The ability to construct such a model indicates that toxicity is a function of a finite number of mechanisms. A comparison of the HeLa SAR model with models that describe other toxicological phenomena demonstrated significant mechanistic similarities with systemic toxicity in rodents and ocular irritation in rabbits. Overall, the present analyses support the hypothesis that the inclusion of a battery of cell toxicity assays together with toxicokinetic models will result in a more predictive model of systemic toxicity in humans.