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The Second ECVAM Workshop on Phototoxicity Testing The Report and Recommendations of ECVAM Workshop 42


Horst Spielmann, Lutz Müller, Dietrich Averbeck, Michael Balls, Susanne Brendler-Schwaab, José V. Castell, Rodger Curren, Odile de Silva, Neil K. Gibbs, Manfred Liebsch, Will W. Lovell, Hans F. Merk, J. Frank Nash, Norbert J. Neumann, Wolfgang J.W. Pape, Peter Ulrich and Hans-Werner Vohr

This is the report of the forty-second of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). To set priorities for collaborative studies, the second ECVAM workshop on in vitro phototoxicity testing was held on 22–27 June 1999, in Berlin at ZEBET (the National German Centre for Documentation and Evaluation of Alternatives to Testing in Animals), at the BgVV (Federal Institute for Health Protection of Consumers and Veterinary Medicine). The workshop was chaired by Horst Spielmann and Lutz Müller (then at BfArM, Berlin, Germany, now at Novartis, Basel, Switzerland), and was attended by photobiologists, toxicologists and photodermatologists from industry, academia and government. The current status of advanced testing methods was discussed, focusing on both the safety of new chemicals in humans and the reduction of testing in animals. A welcome contribution to the workshop was the provision by dermatologists from the Austrian, German and Swiss photopatch test group of unpublished clinical data collected over the past 12 years.