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Alternatives to Laboratory Animals - ATLA

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Preliminary Results of the ECVAM Validation Study on Three In Vitro Embryotoxicity Tests

Horst Spielmann, Elke Genschow, Gabriele Scholz, Nigel A. Brown, Aldert H. Piersma, Madeleine Brady, Nicole Clemann, Hannele Huuskonen, Francoise Paillard, Susanne Bremer and Klaus Becker

According to the report and recommendations of the joint ECVAM/ETS (European Centre for the Validation of Alternative Methods/European Teratology Society) workshop on reproductive toxicology, there is a strong demand for the validation of existing in vitro alternatives to testing in mammals for the potential reproductive toxicity of chemicals. Thus, in 1996, ECVAM officially advertised a call for tenders for conducting a validation study of in vitro embryotoxicity tests.