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Alternatives to Laboratory Animals - ATLA

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Long-term In Vitro Toxicity of 27 MEIC Chemicals on Hep G2 Cells

Ellen. M. Scheers, Barbro Ekwall and Paul J. Dierickx

Extended Abstract


The Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) study led to the development of a battery of in vitro tests, which formed the basis of a strategy for making predictions about the human systemic cytotoxicity of chemicals. Based on the results of the MEIC study and the finding that there were some “missing” tests, a new project, the Evaluation-guided Development of In Vitro Toxicity and Toxicokinetic Tests (EDIT) was initiated.