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Alternatives to Laboratory Animals - ATLA

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The Role of ECVAM in Promoting the Regulatory Acceptance of Alternative Methods in the European Union

Andrew P. Worth and Michael Balls

The roles played by the European Centre for the Validation of Alternative Methods (ECVAM) and its advisory committee, the ECVAM Scientific Advisory Committee (ESAC), in the evolution of alternative methods are described. Particular emphasis is given to the process by which ECVAM and the ESAC assess the scientific validities of alternative methods, and, in appropriate cases, initiate the progression of scientifically validated methods toward regulatory acceptance.