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Alternatives to Laboratory Animals - ATLA

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Statistical Analysis of Monotone or Non-monotone Dose–Response Data from In Vitro Toxicological Assays

Frank Bretz and Ludwig A. Hothorn

Various tests on trend in toxicological studies are reviewed, and the advantages and the disadvantages involved with such procedures are discussed. New tests are introduced to overcome difficulties common to many current procedures, such as downturns at higher doses, and missing numerical availability.