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Alternatives to Laboratory Animals - ATLA

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Experimental Assessment of the Environmental Fate and Effects of Triazoles and Benzotriazole


Mojca Kos Durjava, Boris Kolar, Lovro Arnus, Ester Papa, Simona Kovarich, Ullrika Sahlin and Willie Peijnenburg

The environmental fate and effects of triazoles and benzotriazoles are of concern within the context of chemical regulation. As part of an intelligent testing strategy, experimental tests were performed on endpoints that are relevant for risk assessment. The experimental tests included the assessment of ecotoxicity to an alga, a daphnid and zebrafish embryos, and the assessment of ready biodegradability. Triazole and benzotriazole compounds were selected for testing, based on existing toxicity data for vertebrate and invertebrate species, as well as on the principal component analysis of molecular descriptors aimed at selecting the minimum number of test compounds in order to maximise the chemical domain spanned for both compound classes. The experimental results show that variation in the toxicities of triazoles and benzotriazole across species was relatively minor; in general, the largest factor was approximately 20. The study conducted indicated that triazoles are not readily biodegradable.

Full text pdf 41(1), 65–75