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Alternatives to Laboratory Animals - ATLA

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FRAME and the Validation Process

Michael Balls and Richard Clothier

FRAME’s historical involvement in the development of the principles of validation, whereby the reliability and relevance of a procedure are established for a specific purpose, and in the practical application of the process, is summarised, and examples of participation in various validation studies on in vitro tests are reviewed. Emphasis is placed on the need for a parallel invalidation process, and on the role of ATLA as a forum for objective reporting and discussion on all aspects of the validation process.

Full text pdf 37(6), 631–640