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Alternatives to Laboratory Animals - ATLA

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An Evaluation of Performance Standards and Nonradioactive Endpoints for the Local Lymph Node Assay - The Report and Recommendations of ECVAM Workshop 65

David Basketter, Amanda Cockshott, Emanuela Corsini, G. Frank Gerberick, Kenji Idehara, Ian Kimber, Henk Van Loveren, Joanna Matheson, Annette Mehling, Takashi Omori, Costanza Rovida, Takashi Sozu, Masahiro Takeyoshi and Silvia Casati

This is the report of the 65th of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). A Workshop on An Evaluation of Performance Standards and Non-radioactive Endpoints for the Local Lymph Node Assay was held at ECVAM on 25–27 September 2007, under the chairmanship of David Basketter. The workshop was attended by experts from academia, industry, national organisations, and national and international validation authorities. At present, the local lymph node assay (LLNA) involves the use of radiolabelled thymidine as part of the standard protocol. The aim of the workshop was to review the status of methods which employ non-radioactive endpoints for the LLNA and to consider Performance Standards for their eventual assessment. At the end of the report are listed recommendations that should be considered for progressing toward the validation of relevant and reliable methods.

Full text pdf 36(2), 243–257